Simoniello, Palma ; Wiedemann, Julia ; Zink, Joana ; Thoennes, Eva ; Stange, Maike ; Layer, Paul G. ; Kovacs, Maximilian ; Podda, Maurizio ; Durante, Marco ; Fournier, Claudia (2024)
Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons.
In: Frontiers in Oncology, 2016, 5
doi: 10.26083/tuprints-00016217
Artikel, Zweitveröffentlichung, Verlagsversion
 | Es ist eine neuere Version dieses Eintrags verfügbar. |
Kurzbeschreibung (Abstract)
The increasing application of charged particles in radiotherapy requires a deeper understanding of early and late side effects occurring in skin, which is exposed in all radiation treatments. We measured cellular and molecular changes related to the early inflammatory response of human skin irradiated with carbon ions, in particular cell death induction and changes in differentiation and proliferation of epidermal cells during the first days after exposure. Model systems for human skin from healthy donors of different complexity, i.e., keratinocytes, coculture of skin cells, 3D skin equivalents, and skin explants, were used to investigate the alterations induced by carbon ions (spread-out Bragg peak, dose-averaged LET 100 keV/μm) in comparison to X-ray and UV-B exposure. After exposure to ionizing radiation, in none of the model systems, apoptosis/necrosis was observed. Carbon ions triggered inflammatory signaling and accelerated differentiation of keratinocytes to a similar extent as X-rays at the same doses. High doses of carbon ions were more effective than X-rays in reducing proliferation and inducing abnormal differentiation. In contrast, changes identified following low-dose exposure (≤0.5 Gy) were induced more effectively after X-ray exposure, i.e., enhanced proliferation and change in the polarity of basal cells.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2024 |
| Autor(en): | Simoniello, Palma ; Wiedemann, Julia ; Zink, Joana ; Thoennes, Eva ; Stange, Maike ; Layer, Paul G. ; Kovacs, Maximilian ; Podda, Maurizio ; Durante, Marco ; Fournier, Claudia |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons |
| Sprache: | Englisch |
| Publikationsjahr: | 8 März 2024 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 8 Januar 2016 |
| Ort der Erstveröffentlichung: | Lausanne |
| Verlag: | Frontiers Media S.A. |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frontiers in Oncology |
| Jahrgang/Volume einer Zeitschrift: | 5 |
| Kollation: | 13 Seiten |
| DOI: | 10.26083/tuprints-00016217 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/16217 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | The increasing application of charged particles in radiotherapy requires a deeper understanding of early and late side effects occurring in skin, which is exposed in all radiation treatments. We measured cellular and molecular changes related to the early inflammatory response of human skin irradiated with carbon ions, in particular cell death induction and changes in differentiation and proliferation of epidermal cells during the first days after exposure. Model systems for human skin from healthy donors of different complexity, i.e., keratinocytes, coculture of skin cells, 3D skin equivalents, and skin explants, were used to investigate the alterations induced by carbon ions (spread-out Bragg peak, dose-averaged LET 100 keV/μm) in comparison to X-ray and UV-B exposure. After exposure to ionizing radiation, in none of the model systems, apoptosis/necrosis was observed. Carbon ions triggered inflammatory signaling and accelerated differentiation of keratinocytes to a similar extent as X-rays at the same doses. High doses of carbon ions were more effective than X-rays in reducing proliferation and inducing abnormal differentiation. In contrast, changes identified following low-dose exposure (≤0.5 Gy) were induced more effectively after X-ray exposure, i.e., enhanced proliferation and change in the polarity of basal cells. |
| Freie Schlagworte: | human skin equivalent, keratinocytes, differentiation, apoptosis, inflammation, proliferation, ionizing irradiation, carbon ions |
| ID-Nummer: | Artikel-ID: 294 |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-162175 |
| Zusätzliche Informationen: | This article is part of the Research Topic: Charged Particles in Oncology Specialty section: This article was submitted to Radiation Oncology, a section of the journal Frontiers in Oncology |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Developmental Biology and Neurogenetics 10 Fachbereich Biologie > Radiation Biology and DNA Repair 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) |
| Hinterlegungsdatum: | 08 Mär 2024 13:13 |
| Letzte Änderung: | 11 Mär 2024 06:29 |
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| Suche nach Titel in: | TUfind oder in Google |
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- Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons. (deposited 08 Mär 2024 13:13) [Gegenwärtig angezeigt]
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