Sozhamannan, Shanmuga ; Waldminghaus, Torsten (2024)
Exception to the exception rule: synthetic and naturally occurring single chromosome Vibrio cholerae.
In: Environmental Microbiology, 2020, 22 (10)
doi: 10.26083/tuprints-00016718
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
The genome of Vibrio cholerae, the etiological agent of cholera, is an exception to the single chromosome rule found in the vast majority of bacteria and has its genome partitioned between two unequally sized chromosomes. This unusual two‐chromosome arrangement in V. cholerae has sparked considerable research interest since its discovery. It was demonstrated that the two chromosomes could be fused by deliberate genome engineering or forced to fuse spontaneously by blocking the replication of Chr2, the secondary chromosome. Recently, natural isolates of V. cholerae with chromosomal fusion have been found. Here, we summarize the pertinent findings on this exception to the exception rule and discuss the potential utility of single‐chromosome V. cholerae to address fundamental questions on chromosome biology in general and DNA replication in particular.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2024 |
| Autor(en): | Sozhamannan, Shanmuga ; Waldminghaus, Torsten |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Exception to the exception rule: synthetic and naturally occurring single chromosome Vibrio cholerae |
| Sprache: | Englisch |
| Publikationsjahr: | 29 Januar 2024 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2020 |
| Ort der Erstveröffentlichung: | Oxford |
| Verlag: | John Wiley & Sons |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Environmental Microbiology |
| Jahrgang/Volume einer Zeitschrift: | 22 |
| (Heft-)Nummer: | 10 |
| DOI: | 10.26083/tuprints-00016718 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/16718 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | The genome of Vibrio cholerae, the etiological agent of cholera, is an exception to the single chromosome rule found in the vast majority of bacteria and has its genome partitioned between two unequally sized chromosomes. This unusual two‐chromosome arrangement in V. cholerae has sparked considerable research interest since its discovery. It was demonstrated that the two chromosomes could be fused by deliberate genome engineering or forced to fuse spontaneously by blocking the replication of Chr2, the secondary chromosome. Recently, natural isolates of V. cholerae with chromosomal fusion have been found. Here, we summarize the pertinent findings on this exception to the exception rule and discuss the potential utility of single‐chromosome V. cholerae to address fundamental questions on chromosome biology in general and DNA replication in particular. |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-167186 |
| Zusätzliche Informationen: | Special Issue on Vibrios – from genes to ecosystems |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Molekulare Mikrobiologie Interdisziplinäre Forschungsprojekte Interdisziplinäre Forschungsprojekte > Centre for Synthetic Biology |
| Hinterlegungsdatum: | 29 Jan 2024 13:33 |
| Letzte Änderung: | 30 Jan 2024 07:48 |
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| Suche nach Titel in: | TUfind oder in Google |
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- Exception to the exception rule: synthetic and naturally occurring single chromosome Vibrio cholerae. (deposited 29 Jan 2024 13:33) [Gegenwärtig angezeigt]
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