Ackermann, Eva ; Peixoto, Tiago P. ; Drossel, Barbara (2023)
Reliable dynamics in Boolean and continuous networks.
In: New Journal of Physics, 2012, 14 (12)
doi: 10.26083/tuprints-00020566
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
We investigate the dynamical behavior of a model of robust gene regulatory networks which possess ‘entirely reliable’ trajectories. In a Boolean representation, these trajectories are characterized by being insensitive to the order in which the nodes are updated, i.e. they always go through the same sequence of states. The Boolean model for gene activity is compared with a continuous description in terms of differential equations for the concentrations of mRNA and proteins. We found that entirely reliable Boolean trajectories can be reproduced perfectly in the continuous model when realistic Hill coefficients are used. We investigate to what extent this high correspondence between Boolean and continuous trajectories depends on the extent of reliability of the Boolean trajectories, and we identify simple criteria that enable the faithful reproduction of the Boolean dynamics in the continuous description.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2023 |
| Autor(en): | Ackermann, Eva ; Peixoto, Tiago P. ; Drossel, Barbara |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Reliable dynamics in Boolean and continuous networks |
| Sprache: | Englisch |
| Publikationsjahr: | 5 Dezember 2023 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 18 Dezember 2012 |
| Ort der Erstveröffentlichung: | London |
| Verlag: | IOP Publishing |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | New Journal of Physics |
| Jahrgang/Volume einer Zeitschrift: | 14 |
| (Heft-)Nummer: | 12 |
| Kollation: | 17 Seiten |
| DOI: | 10.26083/tuprints-00020566 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/20566 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | We investigate the dynamical behavior of a model of robust gene regulatory networks which possess ‘entirely reliable’ trajectories. In a Boolean representation, these trajectories are characterized by being insensitive to the order in which the nodes are updated, i.e. they always go through the same sequence of states. The Boolean model for gene activity is compared with a continuous description in terms of differential equations for the concentrations of mRNA and proteins. We found that entirely reliable Boolean trajectories can be reproduced perfectly in the continuous model when realistic Hill coefficients are used. We investigate to what extent this high correspondence between Boolean and continuous trajectories depends on the extent of reliability of the Boolean trajectories, and we identify simple criteria that enable the faithful reproduction of the Boolean dynamics in the continuous description. |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-205666 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) |
| Hinterlegungsdatum: | 05 Dez 2023 10:19 |
| Letzte Änderung: | 08 Dez 2023 13:27 |
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- Reliable dynamics in Boolean and continuous networks. (deposited 05 Dez 2023 10:19) [Gegenwärtig angezeigt]
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