Ackermann, Eva ; Peixoto, Tiago P. ; Drossel, Barbara (2012)
Reliable dynamics in Boolean and continuous networks.
In: New Journal of Physics, 14 (12)
doi: 10.1088/1367-2630/14/12/123029
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
We investigate the dynamical behavior of a model of robust gene regulatory networks which possess 'entirely reliable' trajectories. In a Boolean representation, these trajectories are characterized by being insensitive to the order in which the nodes are updated, i.e. they always go through the same sequence of states. The Boolean model for gene activity is compared with a continuous description in terms of differential equations for the concentrations of mRNA and proteins. We found that entirely reliable Boolean trajectories can be reproduced perfectly in the continuous model when realistic Hill coefficients are used. We investigate to what extent this high correspondence between Boolean and continuous trajectories depends on the extent of reliability of the Boolean trajectories, and we identify simple criteria that enable the faithful reproduction of the Boolean dynamics in the continuous description.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2012 |
| Autor(en): | Ackermann, Eva ; Peixoto, Tiago P. ; Drossel, Barbara |
| Art des Eintrags: | Bibliographie |
| Titel: | Reliable dynamics in Boolean and continuous networks |
| Sprache: | Englisch |
| Publikationsjahr: | 19 Dezember 2012 |
| Verlag: | IOP Publishing |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | New Journal of Physics |
| Jahrgang/Volume einer Zeitschrift: | 14 |
| (Heft-)Nummer: | 12 |
| Kollation: | 17 Seiten |
| DOI: | 10.1088/1367-2630/14/12/123029 |
| URL / URN: | http://iopscience.iop.org/1367-2630/14/12/123029/ |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | We investigate the dynamical behavior of a model of robust gene regulatory networks which possess 'entirely reliable' trajectories. In a Boolean representation, these trajectories are characterized by being insensitive to the order in which the nodes are updated, i.e. they always go through the same sequence of states. The Boolean model for gene activity is compared with a continuous description in terms of differential equations for the concentrations of mRNA and proteins. We found that entirely reliable Boolean trajectories can be reproduced perfectly in the continuous model when realistic Hill coefficients are used. We investigate to what extent this high correspondence between Boolean and continuous trajectories depends on the extent of reliability of the Boolean trajectories, and we identify simple criteria that enable the faithful reproduction of the Boolean dynamics in the continuous description. |
| Zusätzliche Informationen: | Art.No.: 123029; Erstveröffentlichung |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Festkörperphysik (2021 umbenannt in Institut für Physik Kondensierter Materie (IPKM)) 05 Fachbereich Physik > Institut für Festkörperphysik (2021 umbenannt in Institut für Physik Kondensierter Materie (IPKM)) > Statistische Physik und komplexe Systeme 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) |
| Hinterlegungsdatum: | 17 Jan 2013 12:31 |
| Letzte Änderung: | 08 Dez 2023 13:27 |
| PPN: | |
| Zugehörige Links: | |
| Sponsoren: | DFG |
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| Suche nach Titel in: | TUfind oder in Google |
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Reliable dynamics in Boolean and continuous networks. (deposited 05 Dez 2023 10:19)
- Reliable dynamics in Boolean and continuous networks. (deposited 17 Jan 2013 12:31) [Gegenwärtig angezeigt]
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