Mueh, Mario ; Knieß, Robert ; Göringer, H. Ulrich ; Damm, Christian (2023)
Concepts for millimeter wave-based detection of African trypanosomes in field-compatible liquid systems.
In: Frequenz, 2022, 76 (11-12)
doi: 10.26083/tuprints-00023210
Artikel, Zweitveröffentlichung, Verlagsversion
Kurzbeschreibung (Abstract)
Human African Trypanosomiasis (HAT) is caused by the African trypanosome, a single-cell parasite that proliferates in the blood and cerebrospinal fluid of infected patients. Diagnostic measures for this pathogen are currently not sufficiently robust and reliable enough to permit effective disease control procedures. As a consequence, we suggested the development of a new sensor type, combining the selectivity of parasite-specific nucleic acid aptamers with the sensitivity of resonant electromagnetic devices to capture and detect the disease-causing organism. While we accomplished the detection of parasite cells in dehydrated specimens, here we summarize our recent progress toward electromagnetic sensors capable of uncovering parasites in liquid patient samples. We present a technique for the removal of blood cells from blood specimens and the deposition of trypanosome cells on glass microfiber membranes for dielectric spectrometry. Liquid suspensions of trypanosomes are characterized to determine the actual dielectric properties of single parasites and lastly, we present two sensor concepts optimized for the detection in liquids, along with a fabrication technique for the integration of microfluidic sample confinements.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2023 |
| Autor(en): | Mueh, Mario ; Knieß, Robert ; Göringer, H. Ulrich ; Damm, Christian |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Concepts for millimeter wave-based detection of African trypanosomes in field-compatible liquid systems |
| Sprache: | Englisch |
| Publikationsjahr: | 2023 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2022 |
| Verlag: | De Gruyter |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frequenz |
| Jahrgang/Volume einer Zeitschrift: | 76 |
| (Heft-)Nummer: | 11-12 |
| DOI: | 10.26083/tuprints-00023210 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/23210 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung |
| Kurzbeschreibung (Abstract): | Human African Trypanosomiasis (HAT) is caused by the African trypanosome, a single-cell parasite that proliferates in the blood and cerebrospinal fluid of infected patients. Diagnostic measures for this pathogen are currently not sufficiently robust and reliable enough to permit effective disease control procedures. As a consequence, we suggested the development of a new sensor type, combining the selectivity of parasite-specific nucleic acid aptamers with the sensitivity of resonant electromagnetic devices to capture and detect the disease-causing organism. While we accomplished the detection of parasite cells in dehydrated specimens, here we summarize our recent progress toward electromagnetic sensors capable of uncovering parasites in liquid patient samples. We present a technique for the removal of blood cells from blood specimens and the deposition of trypanosome cells on glass microfiber membranes for dielectric spectrometry. Liquid suspensions of trypanosomes are characterized to determine the actual dielectric properties of single parasites and lastly, we present two sensor concepts optimized for the detection in liquids, along with a fabrication technique for the integration of microfluidic sample confinements. |
| Freie Schlagworte: | African trypanosomes, biosensors, microfluidics, microwave sensors, neglected diseases, terahertz |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-232102 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften und Maschinenbau |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Molecular Genetics 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Mikrowellentechnik und Photonik (IMP) |
| TU-Projekte: | DFG|GO516/7-2|Aptera II |
| Hinterlegungsdatum: | 01 Mär 2023 10:11 |
| Letzte Änderung: | 02 Mär 2023 06:10 |
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| Zugehörige Links: | |
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| Suche nach Titel in: | TUfind oder in Google |
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