Luo, Xiaohe ; Lauwers, Marianne ; Layer, Paul G. ; Wen, Chunyi (2021)
Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration.
In: Frontiers in cell and developmental biology, 8
doi: 10.3389/fcell.2020.620543
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
Acetylcholinesterase (AChE), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. The expression of acetylcholinesterase and other cholinergic components is not restricted to only brain and nerve tissues but can also be found in non-neuronal tissues like the immune system and bone tissue. Primary identification of these components has been achieved. However, the information about their specific functions and underlying molecular mechanisms in bone remains scattered. Here, the physiological process of bone development, homeostasis, and degeneration are introduced. Next, the cholinergic system and its expression in bone tissue is documented. Among them, special attention goes to AChE, as the structure of this enzyme suggests diverse binding affinities, enabled by a peripheral site and a catalytic site. The peripheral site supports the non-enzymatic function of AChE in non-neuronal systems. Based on recent studies, the non-neuronal roles of acetylcholinesterase, both enzymatically and non-enzymatically, in bone development, homeostasis and degeneration are summarized briefly together with potential mechanisms to support these functions. We conclude that AChE may be a potential therapeutic target for bone diseases like osteoporosis.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2021 |
| Autor(en): | Luo, Xiaohe ; Lauwers, Marianne ; Layer, Paul G. ; Wen, Chunyi |
| Art des Eintrags: | Bibliographie |
| Titel: | Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration. |
| Sprache: | Englisch |
| Publikationsjahr: | Januar 2021 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frontiers in cell and developmental biology |
| Jahrgang/Volume einer Zeitschrift: | 8 |
| DOI: | 10.3389/fcell.2020.620543 |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | Acetylcholinesterase (AChE), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. The expression of acetylcholinesterase and other cholinergic components is not restricted to only brain and nerve tissues but can also be found in non-neuronal tissues like the immune system and bone tissue. Primary identification of these components has been achieved. However, the information about their specific functions and underlying molecular mechanisms in bone remains scattered. Here, the physiological process of bone development, homeostasis, and degeneration are introduced. Next, the cholinergic system and its expression in bone tissue is documented. Among them, special attention goes to AChE, as the structure of this enzyme suggests diverse binding affinities, enabled by a peripheral site and a catalytic site. The peripheral site supports the non-enzymatic function of AChE in non-neuronal systems. Based on recent studies, the non-neuronal roles of acetylcholinesterase, both enzymatically and non-enzymatically, in bone development, homeostasis and degeneration are summarized briefly together with potential mechanisms to support these functions. We conclude that AChE may be a potential therapeutic target for bone diseases like osteoporosis. |
| ID-Nummer: | pmid:33585459 |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Developmental Biology and Neurogenetics |
| Hinterlegungsdatum: | 23 Feb 2021 07:36 |
| Letzte Änderung: | 06 Dez 2023 09:04 |
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| Suche nach Titel in: | TUfind oder in Google |
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Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration. (deposited 05 Dez 2023 13:44)
- Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration. (deposited 23 Feb 2021 07:36) [Gegenwärtig angezeigt]
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