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Salicylate alters 2-DG uptake in the auditory system: a model for tinnitus?

Wallhäusser-Franke, Elisabeth ; Braun, S. ; Langner, Gerald (1996)
Salicylate alters 2-DG uptake in the auditory system: a model for tinnitus?
In: Neuroreport, 7 (10)
Article, Bibliographie

Abstract

Because salicylate is known to produce tinnitus in humans and animals, the effect of salicylate on the auditory system of gerbils was investigated using [14C]2-deoxyglucose (2-DG). Salicylate treatment reduced activity in the inferior colliculus (IC), particularly in the high frequency part, whereas activation along some isofrequency contours was observed in auditory cortex. In contrast, in saline-treated controls the IC but not the auditory cortex was active. These results suggest that the sensation of subjective tinnitus may be generated within auditory brain structures. The 2-DG method may be used to measure tinnitus objectively in animals and also to evaluate tinnitus treatments.

Item Type: Article
Erschienen: 1996
Creators: Wallhäusser-Franke, Elisabeth ; Braun, S. ; Langner, Gerald
Type of entry: Bibliographie
Title: Salicylate alters 2-DG uptake in the auditory system: a model for tinnitus?
Language: English
Date: 1996
Journal or Publication Title: Neuroreport
Volume of the journal: 7
Issue Number: 10
Abstract:

Because salicylate is known to produce tinnitus in humans and animals, the effect of salicylate on the auditory system of gerbils was investigated using [14C]2-deoxyglucose (2-DG). Salicylate treatment reduced activity in the inferior colliculus (IC), particularly in the high frequency part, whereas activation along some isofrequency contours was observed in auditory cortex. In contrast, in saline-treated controls the IC but not the auditory cortex was active. These results suggest that the sensation of subjective tinnitus may be generated within auditory brain structures. The 2-DG method may be used to measure tinnitus objectively in animals and also to evaluate tinnitus treatments.

Divisions: 10 Department of Biology
Date Deposited: 11 May 2015 12:32
Last Modified: 11 May 2015 12:32
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