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Time domain para hydrogen induced polarization

Ratajczyk, T. ; Gutmann, T. ; Dillenberger, S. ; Abdulhussaein, S. ; Frydel, J. ; Breitzke, H. ; Bommerich, U. ; Trantzschel, T. ; Bernarding, J. ; Magusin, P. C. M. M. ; Buntkowsky, G. (2012)
Time domain para hydrogen induced polarization.
In: Solid State Nuclear Magnetic Resonance, 43-44
Article, Bibliographie

Abstract

Para hydrogen induced polarization (PHIP) is a powerful hyperpolarization technique, which increases the NMR sensitivity by several orders of magnitude. However the hyperpolarized signal is created as an anti-phase signal, which necessitates high magnetic field homogeneity and spectral resolution in the conventional PHIP schemes. This hampers the application of PHIP enhancement in many fields, as for example in food science, materials science or MRI, where low B-0-fields or low B-0-homogeneity do decrease spectral resolution, leading to potential extinction if in-phase and anti-phase hyperpolarization signals cannot be resolved. Herein, we demonstrate that the echo sequence (45 degrees-tau-180 degrees-tau) enables the acquisition of low resolution PHIP enhanced liquid state NMR signals of phenylpropiolic acid derivatives and phenylacetylene at a low cost low-resolution 0.54 T spectrometer. As low field TD-spectrometers are commonly used in industry or biomedicine for the relaxometry of oil-water mixtures, food, nano-particles, or other systems, we compare two variants of para-hydrogen induced polarization with data-evaluation in the time domain (TD-PHIP). In both TD-ALTADENA and the TD-PASADENA strong spin echoes could be detected under conditions when usually no anti-phase signals can be measured due to the lack of resolution. The results suggest that the time-domain detection of PHIP-enhanced signals opens up new application areas for low-field PHIP-hyperpolarization, such as non-invasive compound detection or new contrast agents and biomarkers in low-field Magnetic Resonance Imaging (MRI). Finally, solid-state NMR calculations are presented, which show that the solid echo (90y-tau-90x-tau) version of the TD-ALTADENA experiment is able to convert up to 10 of the PHIP signal into visible magnetization. (C) 2012 Elsevier Inc. All rights reserved.

Item Type: Article
Erschienen: 2012
Creators: Ratajczyk, T. ; Gutmann, T. ; Dillenberger, S. ; Abdulhussaein, S. ; Frydel, J. ; Breitzke, H. ; Bommerich, U. ; Trantzschel, T. ; Bernarding, J. ; Magusin, P. C. M. M. ; Buntkowsky, G.
Type of entry: Bibliographie
Title: Time domain para hydrogen induced polarization
Language: English
Date: 2012
Journal or Publication Title: Solid State Nuclear Magnetic Resonance
Volume of the journal: 43-44
URL / URN: http://apps.webofknowledge.com/full_record.do?product=WOS&se...
Abstract:

Para hydrogen induced polarization (PHIP) is a powerful hyperpolarization technique, which increases the NMR sensitivity by several orders of magnitude. However the hyperpolarized signal is created as an anti-phase signal, which necessitates high magnetic field homogeneity and spectral resolution in the conventional PHIP schemes. This hampers the application of PHIP enhancement in many fields, as for example in food science, materials science or MRI, where low B-0-fields or low B-0-homogeneity do decrease spectral resolution, leading to potential extinction if in-phase and anti-phase hyperpolarization signals cannot be resolved. Herein, we demonstrate that the echo sequence (45 degrees-tau-180 degrees-tau) enables the acquisition of low resolution PHIP enhanced liquid state NMR signals of phenylpropiolic acid derivatives and phenylacetylene at a low cost low-resolution 0.54 T spectrometer. As low field TD-spectrometers are commonly used in industry or biomedicine for the relaxometry of oil-water mixtures, food, nano-particles, or other systems, we compare two variants of para-hydrogen induced polarization with data-evaluation in the time domain (TD-PHIP). In both TD-ALTADENA and the TD-PASADENA strong spin echoes could be detected under conditions when usually no anti-phase signals can be measured due to the lack of resolution. The results suggest that the time-domain detection of PHIP-enhanced signals opens up new application areas for low-field PHIP-hyperpolarization, such as non-invasive compound detection or new contrast agents and biomarkers in low-field Magnetic Resonance Imaging (MRI). Finally, solid-state NMR calculations are presented, which show that the solid echo (90y-tau-90x-tau) version of the TD-ALTADENA experiment is able to convert up to 10 of the PHIP signal into visible magnetization. (C) 2012 Elsevier Inc. All rights reserved.

Uncontrolled Keywords: nmr liquid state nmr para hydrogen induced polarization (phip) nmr signal enhancement time domain nmr spectrometer low field nmr solid-state nmr catalysis parahydrogen-induced polarization nuclear-magnetic-resonance c-13 hyperpolarization spin polarization contrast agents nmr field spectroscopy molecules sensitivity
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948NF Times Cited:8 Cited References Count:49

Divisions: 07 Department of Chemistry
07 Department of Chemistry > Eduard Zintl-Institut > Physical Chemistry
Date Deposited: 27 Oct 2014 20:47
Last Modified: 29 May 2019 11:28
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