TU Darmstadt / ULB / TUbiblio

A novel Ti-based nanoglass composite with submicron–nanometer-sized hierarchical structures to modulate osteoblast behaviors

Chen, Na ; Shi, Xuetao ; Witte, Ralf ; Nakayama, Koji S. ; Ohmura, Kazuyo ; Wu, Hongkai ; Takeuchi, Akira ; Hahn, Horst ; Esashi, Masayoshi ; Gleiter, Herbert ; Inoue, Akihisa ; Louzguine, Dmitri V. (2013)
A novel Ti-based nanoglass composite with submicron–nanometer-sized hierarchical structures to modulate osteoblast behaviors.
In: Journal of Materials Chemistry B, 1 (20)
doi: 10.1039/C3TB20153H
Article, Bibliographie

Abstract

Owing to recent progress in nanotechnology, the ability to tune the surface properties of metals has opened an avenue for creating a new generation of biomaterials. Here we demonstrate the successful development of a novel Ti-based nanoglass composite with submicron–nanometer-sized hierarchical glassy structures. A first exploratory study was performed on the application of the unique nanostructure to modulate osteoblast behaviors. Our results show that this Ti-based nanoglass composite, relative to conventional metallic glasses, exhibits significantly improved biocompatibility. In fact, a 10 times enhancement in cell proliferation has been achieved. To a great extent, this superior bioactivity (such as enhanced cell proliferation and osteogenic phenotype) is promoted by its unique hierarchical structures combining nanoglobules and submicron button-like clusters from collective packing of these nanoglobules. This nanoglass composite could be widely applicable for surface modifications by means of coating on various materials including BMGs, crystalline metals or ceramics. Therefore, our successful experimental testing of this nanostructured metallic glass may open the way to new applications in novel biomaterial design for the purpose of bone replacement.

Item Type: Article
Erschienen: 2013
Creators: Chen, Na ; Shi, Xuetao ; Witte, Ralf ; Nakayama, Koji S. ; Ohmura, Kazuyo ; Wu, Hongkai ; Takeuchi, Akira ; Hahn, Horst ; Esashi, Masayoshi ; Gleiter, Herbert ; Inoue, Akihisa ; Louzguine, Dmitri V.
Type of entry: Bibliographie
Title: A novel Ti-based nanoglass composite with submicron–nanometer-sized hierarchical structures to modulate osteoblast behaviors
Language: English
Date: 28 May 2013
Publisher: Royal Society of Chemistry Publishing
Journal or Publication Title: Journal of Materials Chemistry B
Volume of the journal: 1
Issue Number: 20
DOI: 10.1039/C3TB20153H
Abstract:

Owing to recent progress in nanotechnology, the ability to tune the surface properties of metals has opened an avenue for creating a new generation of biomaterials. Here we demonstrate the successful development of a novel Ti-based nanoglass composite with submicron–nanometer-sized hierarchical glassy structures. A first exploratory study was performed on the application of the unique nanostructure to modulate osteoblast behaviors. Our results show that this Ti-based nanoglass composite, relative to conventional metallic glasses, exhibits significantly improved biocompatibility. In fact, a 10 times enhancement in cell proliferation has been achieved. To a great extent, this superior bioactivity (such as enhanced cell proliferation and osteogenic phenotype) is promoted by its unique hierarchical structures combining nanoglobules and submicron button-like clusters from collective packing of these nanoglobules. This nanoglass composite could be widely applicable for surface modifications by means of coating on various materials including BMGs, crystalline metals or ceramics. Therefore, our successful experimental testing of this nanostructured metallic glass may open the way to new applications in novel biomaterial design for the purpose of bone replacement.

Divisions: 11 Department of Materials and Earth Sciences > Material Science > Joint Research Laboratory Nanomaterials
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences
Date Deposited: 06 Feb 2014 09:23
Last Modified: 06 Feb 2014 09:23
PPN:
Export:
Suche nach Titel in: TUfind oder in Google
Send an inquiry Send an inquiry

Options (only for editors)
Show editorial Details Show editorial Details