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A database search for double-strand containing RNAs in Dictyostelium discoideum.

Gräf, Stefan ; Borisova, Branimira E. ; Nellen, Wolfgang ; Steger, Gerhard ; Hammann, Christian (2004)
A database search for double-strand containing RNAs in Dictyostelium discoideum.
In: Biological chemistry, 385 (10)
Article, Bibliographie

Abstract

In eukaryotic cells, double-stranded RNA is degraded to 21mers and triggers RNA interference. Using a pattern description language, we have searched the EMBL database for sequences with the potential to form double strands in cis in Dictyostelium discoideum. No extended inverted repeats were found in mRNAs. However, the antisense direction of some mRNAs encoding regulatory or developmentally regulated proteins showed the ability to form double-stranded regions. In EST archives, we found potential double strands derived from a few genes, but these transcripts are not continuously encoded in the genome. Most likely, they represent hybrid molecules of sense and antisense RNAs.

Item Type: Article
Erschienen: 2004
Creators: Gräf, Stefan ; Borisova, Branimira E. ; Nellen, Wolfgang ; Steger, Gerhard ; Hammann, Christian
Type of entry: Bibliographie
Title: A database search for double-strand containing RNAs in Dictyostelium discoideum.
Language: English
Date: 2004
Journal or Publication Title: Biological chemistry
Volume of the journal: 385
Issue Number: 10
Abstract:

In eukaryotic cells, double-stranded RNA is degraded to 21mers and triggers RNA interference. Using a pattern description language, we have searched the EMBL database for sequences with the potential to form double strands in cis in Dictyostelium discoideum. No extended inverted repeats were found in mRNAs. However, the antisense direction of some mRNAs encoding regulatory or developmentally regulated proteins showed the ability to form double-stranded regions. In EST archives, we found potential double strands derived from a few genes, but these transcripts are not continuously encoded in the genome. Most likely, they represent hybrid molecules of sense and antisense RNAs.

Divisions: 10 Department of Biology
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10 Department of Biology > Ribogenetics
Date Deposited: 29 Jul 2010 12:21
Last Modified: 05 Mar 2013 09:34
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