TU Darmstadt / ULB / TUbiblio

Biosynthetic, biomimetic, and self-assembled vascularized Organ-on-a-Chip systems

Fritschen, Anna ; Blaeser, Andreas (2023)
Biosynthetic, biomimetic, and self-assembled vascularized Organ-on-a-Chip systems.
In: Biomaterials, 2021, 268
doi: 10.26083/tuprints-00024336
Article, Secondary publication, Postprint

Abstract

Organ-on-a-Chip (OOC) devices have seen major advances in the last years with respect to biological complexity, physiological composition and biomedical relevance. In this context, integration of vasculature has proven to be a crucial element for long-term culture of thick tissue samples as well as for realistic pharmacokinetic, toxicity and metabolic modelling. With the emergence of digital production technologies and the reinvention of existing tools, a multitude of design approaches for guided angio- and vasculogenesis is available today. The underlying production methods can be categorized into biosynthetic, biomimetic and self-assembled vasculature formation. The diversity and importance of production approaches, vascularization strategies as well as biomaterials and cell sourcing are illustrated in this work. A comprehensive technological review with a strong focus on the challenge of producing physiologically relevant vascular structures is given. Finally, the remaining obstacles and opportunities in the development of vascularized Organ-on-a-Chip platforms for advancing drug development and predictive disease modelling are noted.

Item Type: Article
Erschienen: 2023
Creators: Fritschen, Anna ; Blaeser, Andreas
Type of entry: Secondary publication
Title: Biosynthetic, biomimetic, and self-assembled vascularized Organ-on-a-Chip systems
Language: English
Date: 2023
Place of Publication: Darmstadt
Year of primary publication: 2021
Publisher: Elsevier
Journal or Publication Title: Biomaterials
Volume of the journal: 268
Collation: 34 ungezählte Seiten
DOI: 10.26083/tuprints-00024336
URL / URN: https://tuprints.ulb.tu-darmstadt.de/24336
Corresponding Links:
Origin: Secondary publication service
Abstract:

Organ-on-a-Chip (OOC) devices have seen major advances in the last years with respect to biological complexity, physiological composition and biomedical relevance. In this context, integration of vasculature has proven to be a crucial element for long-term culture of thick tissue samples as well as for realistic pharmacokinetic, toxicity and metabolic modelling. With the emergence of digital production technologies and the reinvention of existing tools, a multitude of design approaches for guided angio- and vasculogenesis is available today. The underlying production methods can be categorized into biosynthetic, biomimetic and self-assembled vasculature formation. The diversity and importance of production approaches, vascularization strategies as well as biomaterials and cell sourcing are illustrated in this work. A comprehensive technological review with a strong focus on the challenge of producing physiologically relevant vascular structures is given. Finally, the remaining obstacles and opportunities in the development of vascularized Organ-on-a-Chip platforms for advancing drug development and predictive disease modelling are noted.

Status: Postprint
URN: urn:nbn:de:tuda-tuprints-243367
Classification DDC: 500 Science and mathematics > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 620 Engineering and machine engineering
Divisions: 16 Department of Mechanical Engineering
16 Department of Mechanical Engineering > Institute of Printing Science and Technology (IDD)
16 Department of Mechanical Engineering > Institute of Printing Science and Technology (IDD) > Biomedical Printing Technology (BMT)
Date Deposited: 17 Jul 2023 12:09
Last Modified: 18 Jul 2023 05:28
PPN:
Corresponding Links:
Export:
Suche nach Titel in: TUfind oder in Google
Send an inquiry Send an inquiry

Options (only for editors)
Show editorial Details Show editorial Details