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The application of novel Ir-NHC polarization transfer complexes by SABRE

Hadjiali, Sara ; Bergmann, Marvin ; Kiryutin, Alexey ; Knecht, Stephan ; Sauer, Grit ; Plaumann, Markus ; Limbach, Hans-Heinrich ; Plenio, Herbert ; Buntkowsky, Gerd (2022)
The application of novel Ir-NHC polarization transfer complexes by SABRE.
In: The Journal of Chemical Physics, 151 (24)
doi: 10.26083/tuprints-00019737
Article, Secondary publication, Publisher's Version

Abstract

In recent years, the hyperpolarization method Signal Amplification By Reversible Exchange (SABRE) has developed into a powerful technique to enhance Nuclear Magnetic Resonance (NMR) signals of organic substrates in solution (mostly via binding to the nitrogen lone pair of N-heterocyclic compounds) by several orders of magnitude. In order to establish the application and development of SABRE as a hyperpolarization method for medical imaging, the separation of the Ir-N-Heterocyclic Carbene (Ir-NHC) complex, which facilitates the hyperpolarization of the substrates in solution, is indispensable. Here, we report for the first time the use of novel Ir-NHC complexes with a polymer unit substitution in the backbone of N-Heterocyclic Carbenes (NHC) for SABRE hyperpolarization, which permits the removal of the complexes from solution after the hyperpolarization of a target substrate has been generated.

Item Type: Article
Erschienen: 2022
Creators: Hadjiali, Sara ; Bergmann, Marvin ; Kiryutin, Alexey ; Knecht, Stephan ; Sauer, Grit ; Plaumann, Markus ; Limbach, Hans-Heinrich ; Plenio, Herbert ; Buntkowsky, Gerd
Type of entry: Secondary publication
Title: The application of novel Ir-NHC polarization transfer complexes by SABRE
Language: English
Date: 2022
Publisher: AIP Publishing
Journal or Publication Title: The Journal of Chemical Physics
Volume of the journal: 151
Issue Number: 24
Collation: 7 Seiten
DOI: 10.26083/tuprints-00019737
URL / URN: https://tuprints.ulb.tu-darmstadt.de/19737
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Origin: Secondary publication service
Abstract:

In recent years, the hyperpolarization method Signal Amplification By Reversible Exchange (SABRE) has developed into a powerful technique to enhance Nuclear Magnetic Resonance (NMR) signals of organic substrates in solution (mostly via binding to the nitrogen lone pair of N-heterocyclic compounds) by several orders of magnitude. In order to establish the application and development of SABRE as a hyperpolarization method for medical imaging, the separation of the Ir-N-Heterocyclic Carbene (Ir-NHC) complex, which facilitates the hyperpolarization of the substrates in solution, is indispensable. Here, we report for the first time the use of novel Ir-NHC complexes with a polymer unit substitution in the backbone of N-Heterocyclic Carbenes (NHC) for SABRE hyperpolarization, which permits the removal of the complexes from solution after the hyperpolarization of a target substrate has been generated.

Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-197371
Classification DDC: 500 Science and mathematics > 540 Chemistry
Divisions: 07 Department of Chemistry
07 Department of Chemistry > Eduard Zintl-Institut > Physical Chemistry
Date Deposited: 11 Jan 2022 14:46
Last Modified: 12 Jan 2022 07:19
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