Kav, B. ; Weikl, T. R. ; Deme, B. ; Gege, C. ; Tanaka, M. ; Schneck, E. (2021)
Interplay of trans- and cis-interactions of glycolipids in membrane adhesion.
In: Frontiers in Molecular Biosciences, 8
doi: 10.3389/fmolb.2021.754654
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
Glycolipids mediate stable membrane adhesion of potential biological relevance. In this article, we investigate the trans- and cis-interactions of glycolipids in molecular dynamics simulations and relate these interactions to the glycolipid-induced average separations of membranes obtained from neutron scattering experiments. We find that the cis-interactions between glycolipids in the same membrane leaflet tend to strengthen the trans-interactions between glycolipids in apposing leaflets. The trans-interactions of the glycolipids in our simulations require local membrane separations that are significantly smaller than the average membrane separations in the neutron scattering experiments, which indicates an important role of membrane shape fluctuations in glycolipid trans-binding. Simulations at the experimentally measured average membrane separations provide a molecular picture of the interplay between glycolipid attraction and steric repulsion of the fluctuating membranes probed in the experiments.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2021 |
| Autor(en): | Kav, B. ; Weikl, T. R. ; Deme, B. ; Gege, C. ; Tanaka, M. ; Schneck, E. |
| Art des Eintrags: | Bibliographie |
| Titel: | Interplay of trans- and cis-interactions of glycolipids in membrane adhesion |
| Sprache: | Englisch |
| Publikationsjahr: | 19 November 2021 |
| Verlag: | Frontiers Media S.A. |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frontiers in Molecular Biosciences |
| Jahrgang/Volume einer Zeitschrift: | 8 |
| DOI: | 10.3389/fmolb.2021.754654 |
| URL / URN: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.7546... |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | Glycolipids mediate stable membrane adhesion of potential biological relevance. In this article, we investigate the trans- and cis-interactions of glycolipids in molecular dynamics simulations and relate these interactions to the glycolipid-induced average separations of membranes obtained from neutron scattering experiments. We find that the cis-interactions between glycolipids in the same membrane leaflet tend to strengthen the trans-interactions between glycolipids in apposing leaflets. The trans-interactions of the glycolipids in our simulations require local membrane separations that are significantly smaller than the average membrane separations in the neutron scattering experiments, which indicates an important role of membrane shape fluctuations in glycolipid trans-binding. Simulations at the experimentally measured average membrane separations provide a molecular picture of the interplay between glycolipid attraction and steric repulsion of the fluctuating membranes probed in the experiments. |
| Freie Schlagworte: | glycolipids, carbohydrate–carbohydrate interactions, LewisX carbohydrate, membrane adhesion, membrane shape fluctuations, molecular dynamics (MD) simulations, neutron scattering |
| Zusätzliche Informationen: | Art.No.: 754654, Erstveröffentlichung |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Festkörperphysik (2021 umbenannt in Institut für Physik Kondensierter Materie (IPKM)) 05 Fachbereich Physik > Institut für Festkörperphysik (2021 umbenannt in Institut für Physik Kondensierter Materie (IPKM)) > Physik biologischer weicher Materie |
| Hinterlegungsdatum: | 30 Nov 2021 13:45 |
| Letzte Änderung: | 01 Mär 2024 09:10 |
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| Suche nach Titel in: | TUfind oder in Google |
Verfügbare Versionen dieses Eintrags
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Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion. (deposited 14 Nov 2023 14:19)
- Interplay of trans- and cis-interactions of glycolipids in membrane adhesion. (deposited 30 Nov 2021 13:45) [Gegenwärtig angezeigt]
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