Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix (2018):
FKBP Ligands—Where We Are and Where to Go?
In: Frontiers in Pharmacology, 9, Frontiers, ISSN 1663-9812,
DOI: 10.3389/fphar.2018.01425,
[Article]
Abstract
In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers.
| Item Type: | Article |
|---|---|
| Erschienen: | 2018 |
| Creators: | Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix |
| Title: | FKBP Ligands—Where We Are and Where to Go? |
| Language: | English |
| Abstract: | In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers. |
| Journal or Publication Title: | Frontiers in Pharmacology |
| Volume of the journal: | 9 |
| Publisher: | Frontiers |
| Divisions: | 07 Department of Chemistry 07 Department of Chemistry > Fachgebiet Biochemie |
| Date Deposited: | 24 Feb 2019 20:55 |
| DOI: | 10.3389/fphar.2018.01425 |
| URL / URN: | https://doi.org/10.3389/fphar.2018.01425 |
| URN: | urn:nbn:de:tuda-tuprints-85010 |
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