Rinke, Sebastian ; Naveau, Mikaël ; Wolf, Felix ; Butz-Ostendorf, Markus
Hrsg.: van Ooyen, Arjen ; Butz-Ostendorf, Markus (2017)
Critical Periods Emerge from Homeostatic Structural Plasticity in a Full-Scale Model of the Developing Cortical Column.
In: The Rewiring Brain: A Computational Approach to Structural Plasticity in the Adult Brain, Auflage: 1. Auflage
doi: 10.1016/B978-0-12-803784-3.00008-1
Buchkapitel, Bibliographie
Kurzbeschreibung (Abstract)
From detailed large-scale models of the cortical column, we have today a good understanding how activity propagates following synaptic connectivity across the different cortical layers. However, the understanding of how the underlying connectivity is shaped remains an open question as large-scale models so far use fixed connectivity only. With the modeling approaches described in this chapter, it became possible to explore how the reciprocal interaction of electrical activity, connectivity, and synaptogenesis forms connections between the different cell types within one layer and across several layers. The resulted connectivity showed remarkable similarity with real anatomical connectivity of a cortical column. The course of network formation shows a phase of pronounced excitatory synapse formation which we interpreted as a “critical period” during cortical column development. The timing of the critical period in the model is set by the developing inhibition. The critical period opens as soon as the influence of inhibitory neurons on excitatory neurons grows strong and closes when the inhibitory neurons reached their set-point activity. The effect could explain why benzodiazepines like diazepam can advance the opening of critical periods during brain development. The large-scale model of the cortical column was simulated by the MSP (Model of Structural Plasticity by Butz et al.) framework in the spiking neuron simulator NEST (www.nest-initiative.org). We further detail an approach of simulating MSP in even larger networks than 106, with the size being merely limited by the memory capacity making MSP ready for the next generation of supercomputers.
| Typ des Eintrags: | Buchkapitel |
|---|---|
| Erschienen: | 2017 |
| Herausgeber: | van Ooyen, Arjen ; Butz-Ostendorf, Markus |
| Autor(en): | Rinke, Sebastian ; Naveau, Mikaël ; Wolf, Felix ; Butz-Ostendorf, Markus |
| Art des Eintrags: | Bibliographie |
| Titel: | Critical Periods Emerge from Homeostatic Structural Plasticity in a Full-Scale Model of the Developing Cortical Column |
| Sprache: | Englisch |
| Publikationsjahr: | 2017 |
| Verlag: | Academic Press |
| Buchtitel: | The Rewiring Brain: A Computational Approach to Structural Plasticity in the Adult Brain |
| Veranstaltungsort: | San Diego |
| Auflage: | 1. Auflage |
| DOI: | 10.1016/B978-0-12-803784-3.00008-1 |
| URL / URN: | https://www.sciencedirect.com/book/9780128037843/the-rewirin... |
| Kurzbeschreibung (Abstract): | From detailed large-scale models of the cortical column, we have today a good understanding how activity propagates following synaptic connectivity across the different cortical layers. However, the understanding of how the underlying connectivity is shaped remains an open question as large-scale models so far use fixed connectivity only. With the modeling approaches described in this chapter, it became possible to explore how the reciprocal interaction of electrical activity, connectivity, and synaptogenesis forms connections between the different cell types within one layer and across several layers. The resulted connectivity showed remarkable similarity with real anatomical connectivity of a cortical column. The course of network formation shows a phase of pronounced excitatory synapse formation which we interpreted as a “critical period” during cortical column development. The timing of the critical period in the model is set by the developing inhibition. The critical period opens as soon as the influence of inhibitory neurons on excitatory neurons grows strong and closes when the inhibitory neurons reached their set-point activity. The effect could explain why benzodiazepines like diazepam can advance the opening of critical periods during brain development. The large-scale model of the cortical column was simulated by the MSP (Model of Structural Plasticity by Butz et al.) framework in the spiking neuron simulator NEST (www.nest-initiative.org). We further detail an approach of simulating MSP in even larger networks than 106, with the size being merely limited by the memory capacity making MSP ready for the next generation of supercomputers. |
| Fachbereich(e)/-gebiet(e): | 20 Fachbereich Informatik 20 Fachbereich Informatik > Parallele Programmierung DFG-Graduiertenkollegs DFG-Graduiertenkollegs > Graduiertenkolleg 1994 Adaptive Informationsaufbereitung aus heterogenen Quellen |
| Hinterlegungsdatum: | 18 Jan 2018 11:44 |
| Letzte Änderung: | 13 Jun 2024 08:27 |
| PPN: | 519108698 |
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