Guthausen, Gisela and Machado, Julyana R. and Luy, Burkhard and Baniodeh, Amer and Powell, Annie K. and Kramer, Steffen and Ranzinger, Florian and Herrling, Maria P. and Lackner, Susanne and Horn, Harald (2015):
Characterisation and application of ultra-high spin clusters as magnetic resonance relaxation agents.
In: Dalton Transactions, 44 (11), RSC, pp. 5032-5040, ISSN 1477-9226,
[Online-Edition: http://dx.doi.org/10.1039/C4DT02916J],
[Article]
Abstract
In Magnetic Resonance Tomography (MRT) image contrast can be improved by adding paramagnetic relaxation agents such as lanthanide ions. Here we report on the use of highly paramagnetic isostructural FeIII/4f coordination clusters with a [Fe10Ln10] core to enhance relaxation. Measurements were performed over the range of 1H Larmor frequencies of 10 MHz to 1.4 GHz in order to determine the relevant parameters for longitudinal and transverse relaxivities. Variation of the lanthanide ion allows differentiation of relaxation contributions from electronic states and molecular dynamics. We find that the transverse relaxivities increase with field, whereas the longitudinal relaxivities depend on the nature of the lanthanide. In addition, the GdIII analogue was selected in particular to test the interaction with tissue observed using MRT. Studies on biofilms used in waste water treatment reveal that the behaviour of the high-spin clusters is different from what is observed for common relaxation agents with respect to the penetration into the biofilms. The Fe10Gd10 cluster adheres to the surface of the biofilm better than the commercial agent Gadovist.
| Item Type: | Article |
|---|---|
| Erschienen: | 2015 |
| Creators: | Guthausen, Gisela and Machado, Julyana R. and Luy, Burkhard and Baniodeh, Amer and Powell, Annie K. and Kramer, Steffen and Ranzinger, Florian and Herrling, Maria P. and Lackner, Susanne and Horn, Harald |
| Title: | Characterisation and application of ultra-high spin clusters as magnetic resonance relaxation agents |
| Language: | English |
| Abstract: | In Magnetic Resonance Tomography (MRT) image contrast can be improved by adding paramagnetic relaxation agents such as lanthanide ions. Here we report on the use of highly paramagnetic isostructural FeIII/4f coordination clusters with a [Fe10Ln10] core to enhance relaxation. Measurements were performed over the range of 1H Larmor frequencies of 10 MHz to 1.4 GHz in order to determine the relevant parameters for longitudinal and transverse relaxivities. Variation of the lanthanide ion allows differentiation of relaxation contributions from electronic states and molecular dynamics. We find that the transverse relaxivities increase with field, whereas the longitudinal relaxivities depend on the nature of the lanthanide. In addition, the GdIII analogue was selected in particular to test the interaction with tissue observed using MRT. Studies on biofilms used in waste water treatment reveal that the behaviour of the high-spin clusters is different from what is observed for common relaxation agents with respect to the penetration into the biofilms. The Fe10Gd10 cluster adheres to the surface of the biofilm better than the commercial agent Gadovist. |
| Journal or Publication Title: | Dalton Transactions |
| Volume: | 44 |
| Number: | 11 |
| Publisher: | RSC |
| Divisions: | 13 Department of Civil and Environmental Engineering Sciences > Institute IWAR > Wastewater Engineering 13 Department of Civil and Environmental Engineering Sciences > Institute IWAR 13 Department of Civil and Environmental Engineering Sciences |
| Date Deposited: | 13 Jul 2017 08:22 |
| Official URL: | http://dx.doi.org/10.1039/C4DT02916J |
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