Baumeister, Dirk ; Hertel, Brigitte ; Schroeder, Indra ; Gazzarrini, Sabrina ; Kast, Stefan M. ; Etten, James L. van ; Moroni, Anna ; Thiel, Gerhard (2017)
Conversion of an instantaneous activating K(+) channel into a slow activating inward rectifier.
In: FEBS letters, 591 (2)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
The miniature channel, Kcv, is a structural equivalent of the pore of all K(+) channels. Here, we follow up on a previous observation that a largely voltage-insensitive channel can be converted into a slow activating inward rectifier after extending the outer transmembrane domain by one Ala. This gain of rectification can be rationalized by dynamic salt bridges at the cytosolic entrance to the channel; opening is favored by voltage-sensitive formation of salt bridges and counteracted by their disruption. Such latent voltage sensitivity in the pore could be relevant for the understanding of voltage gating in complex Kv channels.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2017 |
| Autor(en): | Baumeister, Dirk ; Hertel, Brigitte ; Schroeder, Indra ; Gazzarrini, Sabrina ; Kast, Stefan M. ; Etten, James L. van ; Moroni, Anna ; Thiel, Gerhard |
| Art des Eintrags: | Bibliographie |
| Titel: | Conversion of an instantaneous activating K(+) channel into a slow activating inward rectifier. |
| Sprache: | Englisch |
| Publikationsjahr: | 2017 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | FEBS letters |
| Jahrgang/Volume einer Zeitschrift: | 591 |
| (Heft-)Nummer: | 2 |
| Kurzbeschreibung (Abstract): | The miniature channel, Kcv, is a structural equivalent of the pore of all K(+) channels. Here, we follow up on a previous observation that a largely voltage-insensitive channel can be converted into a slow activating inward rectifier after extending the outer transmembrane domain by one Ala. This gain of rectification can be rationalized by dynamic salt bridges at the cytosolic entrance to the channel; opening is favored by voltage-sensitive formation of salt bridges and counteracted by their disruption. Such latent voltage sensitivity in the pore could be relevant for the understanding of voltage gating in complex Kv channels. |
| ID-Nummer: | pmid:27995608 |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Plant Membrane Biophyscis (am 20.12.23 umbenannt in Biologie der Algen und Protozoen) |
| Hinterlegungsdatum: | 04 Jan 2017 11:21 |
| Letzte Änderung: | 20 Aug 2021 09:43 |
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