Leemhuis, Hans ; Stein, Viktor ; Griffiths, Andrew D. ; Hollfelder, Florian (2005)
New genotype-phenotype linkages for directed evolution of functional proteins.
In: Current opinion in structural biology, 15 (4)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
The key practical consideration in directed evolution of functional biomolecules is the linkage of genotype and phenotype. In vitro selections offer the potential to select from libraries with up to 10(10)-10(14) members, with fewer constraints than current cell-based selections. New approaches such as mRNA display, ribosome display and in vitro compartmentalisation have complementary areas of application in selections for binding or catalysis.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2005 |
| Autor(en): | Leemhuis, Hans ; Stein, Viktor ; Griffiths, Andrew D. ; Hollfelder, Florian |
| Art des Eintrags: | Bibliographie |
| Titel: | New genotype-phenotype linkages for directed evolution of functional proteins. |
| Sprache: | Englisch |
| Publikationsjahr: | 2005 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Current opinion in structural biology |
| Jahrgang/Volume einer Zeitschrift: | 15 |
| (Heft-)Nummer: | 4 |
| Kurzbeschreibung (Abstract): | The key practical consideration in directed evolution of functional biomolecules is the linkage of genotype and phenotype. In vitro selections offer the potential to select from libraries with up to 10(10)-10(14) members, with fewer constraints than current cell-based selections. New approaches such as mRNA display, ribosome display and in vitro compartmentalisation have complementary areas of application in selections for binding or catalysis. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Protein Engineering of Ion Conducting Nanopores |
| Hinterlegungsdatum: | 14 Nov 2016 11:59 |
| Letzte Änderung: | 14 Nov 2016 11:59 |
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