Prost, Gaëlle ; Braun, Sebastian ; Hertwig, Falk ; Winkler, Marcus ; Jagemann, Lucas ; Nolbrant, Sara ; Leefa, Isabelle V. ; Offen, Nils ; Miharada, Kenichi ; Lang, Stefan ; Artner, Isabella ; Nuber, Ulrike A. (2016)
The putative tumor suppressor gene EphA7 is a novel BMI-1 target.
In: Oncotarget, 7 (36)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Bmi1 was originally identified as a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and Arf. It codes for the Polycomb group protein BMI-1 and acts primarily as a transcriptional repressor via chromatin modifications. Although it binds to a large number of genomic regions, the direct BMI-1 target genes described so far do not explain the full spectrum of BMI-1-mediated effects. Here we identify the putative tumor suppressor gene EphA7 as a novel direct BMI-1 target in neural cells and lymphocytes. EphA7 silencing has been reported in several different human tumor types including lymphomas, and our data suggest BMI1 overexpression as a novel mechanism leading to EphA7 inactivation via H3K27 trimethylation and DNA methylation.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2016 |
| Autor(en): | Prost, Gaëlle ; Braun, Sebastian ; Hertwig, Falk ; Winkler, Marcus ; Jagemann, Lucas ; Nolbrant, Sara ; Leefa, Isabelle V. ; Offen, Nils ; Miharada, Kenichi ; Lang, Stefan ; Artner, Isabella ; Nuber, Ulrike A. |
| Art des Eintrags: | Bibliographie |
| Titel: | The putative tumor suppressor gene EphA7 is a novel BMI-1 target. |
| Sprache: | Englisch |
| Publikationsjahr: | 2016 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Oncotarget |
| Jahrgang/Volume einer Zeitschrift: | 7 |
| (Heft-)Nummer: | 36 |
| Kurzbeschreibung (Abstract): | Bmi1 was originally identified as a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and Arf. It codes for the Polycomb group protein BMI-1 and acts primarily as a transcriptional repressor via chromatin modifications. Although it binds to a large number of genomic regions, the direct BMI-1 target genes described so far do not explain the full spectrum of BMI-1-mediated effects. Here we identify the putative tumor suppressor gene EphA7 as a novel direct BMI-1 target in neural cells and lymphocytes. EphA7 silencing has been reported in several different human tumor types including lymphomas, and our data suggest BMI1 overexpression as a novel mechanism leading to EphA7 inactivation via H3K27 trimethylation and DNA methylation. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Stammzell- und Entwicklungsbiologie |
| Hinterlegungsdatum: | 30 Aug 2016 09:55 |
| Letzte Änderung: | 10 Jan 2017 11:20 |
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