Ali, Mubarak ; Ahmed, Ishtiaq ; Ramirez, Patricio ; Nasir, Saima ; Niemeyer, Christof M. ; Mafe, Salvador ; Ensinger, Wolfgang (2016)
Label-Free Pyrophosphate Recognition with Functionalized Asymmetric Nanopores.
In: Small, 12 (15)
doi: 10.1002/smll.201600160
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
The label-free detection of pyrophosphate (PPi) anions with a nanofluidic sensing device based on asymmetric nanopores is demonstrated. The pore surface is functionalized with zinc complexes based on two di(2-picolyl)amine [bis(DPA)] moieties using carbodiimide coupling chemistry. The complexation of zinc (Zn2+) ion is achieved by exposing the modified pore to a solution of zinc chloride to form bis(Zn2+-DPA) complexes. The chemical functionalization is demonstrated by recording the changes in the observed current-voltage (I-V) curves before and after pore modification. The bis(Zn2+-DPA) complexes on the pore walls serve as recognition sites for pyrophosphate anion. The experimental results show that the proposed nanofluidic sensor has the ability to sense picomolar concentrations of PPi anion in the surrounding environment. On the contrary, it does not respond to other phosphate anions, including monohydrogen phosphate, dihydrogen phosphate, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate. The experimental results are described theoretically by using a model based on the Poisson-Nernst-Planck equations.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2016 |
| Autor(en): | Ali, Mubarak ; Ahmed, Ishtiaq ; Ramirez, Patricio ; Nasir, Saima ; Niemeyer, Christof M. ; Mafe, Salvador ; Ensinger, Wolfgang |
| Art des Eintrags: | Bibliographie |
| Titel: | Label-Free Pyrophosphate Recognition with Functionalized Asymmetric Nanopores |
| Sprache: | Englisch |
| Publikationsjahr: | 20 April 2016 |
| Verlag: | WILEY-V C H VERLAG GMBH, WEINHEIM, GERMANY |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Small |
| Jahrgang/Volume einer Zeitschrift: | 12 |
| (Heft-)Nummer: | 15 |
| DOI: | 10.1002/smll.201600160 |
| Kurzbeschreibung (Abstract): | The label-free detection of pyrophosphate (PPi) anions with a nanofluidic sensing device based on asymmetric nanopores is demonstrated. The pore surface is functionalized with zinc complexes based on two di(2-picolyl)amine [bis(DPA)] moieties using carbodiimide coupling chemistry. The complexation of zinc (Zn2+) ion is achieved by exposing the modified pore to a solution of zinc chloride to form bis(Zn2+-DPA) complexes. The chemical functionalization is demonstrated by recording the changes in the observed current-voltage (I-V) curves before and after pore modification. The bis(Zn2+-DPA) complexes on the pore walls serve as recognition sites for pyrophosphate anion. The experimental results show that the proposed nanofluidic sensor has the ability to sense picomolar concentrations of PPi anion in the surrounding environment. On the contrary, it does not respond to other phosphate anions, including monohydrogen phosphate, dihydrogen phosphate, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate. The experimental results are described theoretically by using a model based on the Poisson-Nernst-Planck equations. |
| Freie Schlagworte: | current rectification, functionalization, sensors, pyrophosphate, track-etching, Zn(II)-dipicolylamine complexes |
| Fachbereich(e)/-gebiet(e): | 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft > Fachgebiet Materialanalytik 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft 11 Fachbereich Material- und Geowissenschaften |
| Hinterlegungsdatum: | 06 Jun 2016 11:55 |
| Letzte Änderung: | 06 Jun 2016 11:55 |
| PPN: | |
| Sponsoren: | M.A., S.N., and W.E. acknowledge the funding from the Hessen State Ministry of Higher Education, Research and the Arts, Germany, under the LOEWE project iNAPO., P.R. and S.M. acknowledge financial support by the Generalitat Valenciana (Program of Excellence Prometeo/GV/0069), the Spanish Ministry of Economic Affairs and Competitiveness (MAT2015-65011-P), and FEDER.I. A. and C.M.N. acknowledge financial support th, I. A. and C.M.N. acknowledge financial support through the Helmholtz programme BioInterfaces in Technology and Medicine. |
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