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A novel cationic copper(II) Schiff base complex: Synthesis, characterization, crystal structure, electrochemical evaluation, anti-cancer activity, and preparation of its metal oxide nanoparticles

Ebrahimipour, S. Yousef and Sheikhshoaie, Iran and Castro, Jesús and Haase, Wolfgang and Mohamadi, Maryam and Foro, Sabine and Sheikhshoaie, Mahdie and Esmaeili-Mahani, Saeed (2015):
A novel cationic copper(II) Schiff base complex: Synthesis, characterization, crystal structure, electrochemical evaluation, anti-cancer activity, and preparation of its metal oxide nanoparticles.
In: Inorganica Chimica Acta, ELSEVIER SCIENCE SA, Switzerland, pp. 245-252, 430, ISSN 00201693,
[Online-Edition: http://dx.doi.org/10.1016/j.ica.2015.03.016],
[Article]

Abstract

A tridentate ONO ligand (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide [HL] and its cationic Cu(II) complex [Cu(L)(H2O)]NO3 were synthesized and characterized by means of elemental analysis, FT-IR and UV-Vis spectrometry and conductivity measurements. The structure of the complex was determined using single crystal X-ray diffraction. The obtained data revealed that the Cu(II) center is coordinated by two oxygens and one nitrogen of the ligand. The fourth position is occupied by oxygen atom of a coordinated water molecule. X-ray data obtained showed that this complex possessed distorted square planar geometry around Cu(II) ion. Nitrate anion as the counter ion occupied the second sphere around the Cu(II) center via hydrogen bonding. The electrochemical behavior of the free ligand and its Cu(II) complex were studied using cyclic voltammetry. Nanoparticles (NPs) of CuO with the average size of 23 nm were prepared with thermal decomposition of the title complex and then were characterized using X-ray powder diffraction (XRD). Anti-cancer activities of the title compounds against human breast cancer (MCF-7 cells viability) were investigated and compared with each other. It was found that [Cu(L)(H2O)]NO3 complex showed higher anticancer activity than the others. (C) 2015 Elsevier B.V. All rights reserved.

Item Type: Article
Erschienen: 2015
Creators: Ebrahimipour, S. Yousef and Sheikhshoaie, Iran and Castro, Jesús and Haase, Wolfgang and Mohamadi, Maryam and Foro, Sabine and Sheikhshoaie, Mahdie and Esmaeili-Mahani, Saeed
Title: A novel cationic copper(II) Schiff base complex: Synthesis, characterization, crystal structure, electrochemical evaluation, anti-cancer activity, and preparation of its metal oxide nanoparticles
Language: English
Abstract:

A tridentate ONO ligand (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide [HL] and its cationic Cu(II) complex [Cu(L)(H2O)]NO3 were synthesized and characterized by means of elemental analysis, FT-IR and UV-Vis spectrometry and conductivity measurements. The structure of the complex was determined using single crystal X-ray diffraction. The obtained data revealed that the Cu(II) center is coordinated by two oxygens and one nitrogen of the ligand. The fourth position is occupied by oxygen atom of a coordinated water molecule. X-ray data obtained showed that this complex possessed distorted square planar geometry around Cu(II) ion. Nitrate anion as the counter ion occupied the second sphere around the Cu(II) center via hydrogen bonding. The electrochemical behavior of the free ligand and its Cu(II) complex were studied using cyclic voltammetry. Nanoparticles (NPs) of CuO with the average size of 23 nm were prepared with thermal decomposition of the title complex and then were characterized using X-ray powder diffraction (XRD). Anti-cancer activities of the title compounds against human breast cancer (MCF-7 cells viability) were investigated and compared with each other. It was found that [Cu(L)(H2O)]NO3 complex showed higher anticancer activity than the others. (C) 2015 Elsevier B.V. All rights reserved.

Journal or Publication Title: Inorganica Chimica Acta
Volume: 430
Publisher: ELSEVIER SCIENCE SA, Switzerland
Uncontrolled Keywords: Schiff base ONO ligand, Copper(II) complex, Cell viability, Electrochemical behavior, X-ray diffraction
Divisions: 11 Department of Materials and Earth Sciences > Material Science > Structure Research
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences
Date Deposited: 21 Jan 2016 12:02
Official URL: http://dx.doi.org/10.1016/j.ica.2015.03.016
Identification Number: doi:10.1016/j.ica.2015.03.016
Funders: Authors gratefully acknowledge the financial support provided for this work by the Shahid Bahonar University of Kerman.
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