Hegemann, B. ; Unger, M. ; Lee, S. S. ; Stoffel-Studer, I. ; Heuvel, J. van den ; Pelet, S. ; Koeppl, H. ; Peter, M. (2015)
A Cellular System for Spatial Signal Decoding in Chemical Gradients.
In: Developmental Cell, 35 (4)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Directional cell growth requires that cells read and interpret shallow chemical gradients, but how the gradient directional information is identified remains elusive. We use single-cell analysis and mathematical modeling to define the cellular gradient decoding network in yeast. Our results demonstrate that the spatial information of the gradient signal is read locally within the polarity site complex using double-positive feedback between the GTPase Cdc42 and trafficking of the receptor Ste2. Spatial decoding critically depends on low Cdc42 activity, which is maintained by the MAPK Fus3 through sequestration of the Cdc42 activator Cdc24. Deregulated Cdc42 or Ste2 trafficking prevents gradient decoding and leads to mis-oriented growth. Our work discovers how a conserved set of components assembles a network integrating signal intensity and directionality to decode the spatial information contained in chemical gradients.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2015 |
| Autor(en): | Hegemann, B. ; Unger, M. ; Lee, S. S. ; Stoffel-Studer, I. ; Heuvel, J. van den ; Pelet, S. ; Koeppl, H. ; Peter, M. |
| Art des Eintrags: | Bibliographie |
| Titel: | A Cellular System for Spatial Signal Decoding in Chemical Gradients |
| Sprache: | Englisch |
| Publikationsjahr: | 23 November 2015 |
| Verlag: | Elsevier |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Developmental Cell |
| Jahrgang/Volume einer Zeitschrift: | 35 |
| (Heft-)Nummer: | 4 |
| URL / URN: | http://www.cell.com/developmental-cell/fulltext/S1534-5807%2... |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | Directional cell growth requires that cells read and interpret shallow chemical gradients, but how the gradient directional information is identified remains elusive. We use single-cell analysis and mathematical modeling to define the cellular gradient decoding network in yeast. Our results demonstrate that the spatial information of the gradient signal is read locally within the polarity site complex using double-positive feedback between the GTPase Cdc42 and trafficking of the receptor Ste2. Spatial decoding critically depends on low Cdc42 activity, which is maintained by the MAPK Fus3 through sequestration of the Cdc42 activator Cdc24. Deregulated Cdc42 or Ste2 trafficking prevents gradient decoding and leads to mis-oriented growth. Our work discovers how a conserved set of components assembles a network integrating signal intensity and directionality to decode the spatial information contained in chemical gradients. |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik > Bioinspirierte Kommunikationssysteme 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik |
| Hinterlegungsdatum: | 08 Dez 2015 11:09 |
| Letzte Änderung: | 23 Sep 2021 14:31 |
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