Pedrolli, Danielle Biscaro ; Kühm, Christian ; Sévin, Daniel C. ; Vockenhuber, Michael P. ; Sauer, Uwe ; Suess, Beatrix ; Mack, Matthias (2015)
A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis.
In: Proceedings of the National Academy of Sciences of the United States of America, 112 (45)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Flavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes responsible for biosynthesis and/or transport of riboflavin (rib genes). Cytoplasmic riboflavin is rapidly and almost completely converted to FMN by flavokinases. When cytoplasmic levels of FMN are sufficient ("high levels"), FMN binding to FMN riboswitches leads to a reduction of rib gene expression. We report here that the protein RibR counteracts the FMN-induced "turn-off" activities of both FMN riboswitches in Bacillus subtilis, allowing rib gene expression even in the presence of high levels of FMN. The reason for this secondary metabolic control by RibR is to couple sulfur metabolism with riboflavin metabolism.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2015 |
| Autor(en): | Pedrolli, Danielle Biscaro ; Kühm, Christian ; Sévin, Daniel C. ; Vockenhuber, Michael P. ; Sauer, Uwe ; Suess, Beatrix ; Mack, Matthias |
| Art des Eintrags: | Bibliographie |
| Titel: | A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis. |
| Sprache: | Englisch |
| Publikationsjahr: | 2015 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Proceedings of the National Academy of Sciences of the United States of America |
| Jahrgang/Volume einer Zeitschrift: | 112 |
| (Heft-)Nummer: | 45 |
| Kurzbeschreibung (Abstract): | Flavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes responsible for biosynthesis and/or transport of riboflavin (rib genes). Cytoplasmic riboflavin is rapidly and almost completely converted to FMN by flavokinases. When cytoplasmic levels of FMN are sufficient ("high levels"), FMN binding to FMN riboswitches leads to a reduction of rib gene expression. We report here that the protein RibR counteracts the FMN-induced "turn-off" activities of both FMN riboswitches in Bacillus subtilis, allowing rib gene expression even in the presence of high levels of FMN. The reason for this secondary metabolic control by RibR is to couple sulfur metabolism with riboflavin metabolism. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Synthetic Genetic Circuits (2020 umbenannt in "Synthetic RNA biology") |
| Hinterlegungsdatum: | 09 Nov 2015 08:09 |
| Letzte Änderung: | 22 Dez 2015 11:25 |
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