Voss, Agnieszka ; Dietz, Christian ; Stocker, Annika ; Stark, Robert W. (2015)
Quantitative measurement of the mechanical properties of human antibodies with sub-10-nm resolution in a liquid environment.
In: Nano Research, 8 (6)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
The nanomechanical properties of single human immunoglobulin G and M antibodies were measured in a liquid environment using a fast force-volume technique with sub-10-nm spatial resolution. The ultrastructural details of these molecules were resolved in the images. Simultaneously, important physical properties, including elasticity, adhesion, and deformation were measured. The dimensions and adsorption of the immunoglobulin M antibodies onto the substrate indicated that they are highly flexible. The antibodies were characterized by a low elastic stiffness (34 +/- 10 MPa) and high deformability (1.5 +/- 0.5 nm).
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2015 |
| Autor(en): | Voss, Agnieszka ; Dietz, Christian ; Stocker, Annika ; Stark, Robert W. |
| Art des Eintrags: | Bibliographie |
| Titel: | Quantitative measurement of the mechanical properties of human antibodies with sub-10-nm resolution in a liquid environment |
| Sprache: | Englisch |
| Publikationsjahr: | Juni 2015 |
| Verlag: | TSINGHUA UNIV PRESS, TSINGHUA UNIV, BEIJING, PEOPLES R CHINA |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Nano Research |
| Jahrgang/Volume einer Zeitschrift: | 8 |
| (Heft-)Nummer: | 6 |
| URL / URN: | http://dx.doi.org/10.1007/s12274-015-0710-5 |
| Kurzbeschreibung (Abstract): | The nanomechanical properties of single human immunoglobulin G and M antibodies were measured in a liquid environment using a fast force-volume technique with sub-10-nm spatial resolution. The ultrastructural details of these molecules were resolved in the images. Simultaneously, important physical properties, including elasticity, adhesion, and deformation were measured. The dimensions and adsorption of the immunoglobulin M antibodies onto the substrate indicated that they are highly flexible. The antibodies were characterized by a low elastic stiffness (34 +/- 10 MPa) and high deformability (1.5 +/- 0.5 nm). |
| Freie Schlagworte: | atomic force microscopy, structure and physical properties, piconewton forces, flexibility, antibodies, immunoglobulin |
| Fachbereich(e)/-gebiet(e): | 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft > Fachgebiet Physics of Surfaces Zentrale Einrichtungen 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft 11 Fachbereich Material- und Geowissenschaften Exzellenzinitiative Exzellenzinitiative > Exzellenzcluster Profilbereiche > Thermo-Fluids & Interfaces Profilbereiche |
| Hinterlegungsdatum: | 31 Aug 2015 14:22 |
| Letzte Änderung: | 21 Sep 2016 11:28 |
| PPN: | |
| Sponsoren: | The authors thank the Center of Smart Interface for financial support. |
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