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Synthesis and in vitro bioactivity assessment of injectable bioglass−organic pastes for bone tissue repair

Tulyaganov, D. U. and Reddy, A. A. and Siegel, R. and Ionescu, E. and Riedel, R. and Ferreira, J. M. F. (2015):
Synthesis and in vitro bioactivity assessment of injectable bioglass−organic pastes for bone tissue repair.
41, In: Ceramics International, (8), pp. 9373-9382, ISSN 02728842, [Online-Edition: http://dx.doi.org/10.1016/j.ceramint.2015.03.312],
[Article]

Abstract

The aim of this work was to study the bioactivity of systems based on a clinically tested bioactive glass (BG) particulates (mol%: 4.33 Na2O−30.30 CaO−12.99 MgO−45.45 SiO2−2.60 P2O5−4.33 CaF2) and organic carriers. The cohesiveness of injectable bone graft products is of high relevance when filling complex volumetric bone defects. With this motivation behind, BG particulates with mean sizes within 11−14 μm were mixed in different proportions with glycerol (G) and polyethylene glycol (PEG) as organic carriers and the mixtures were fully injectable exhibiting Newtonian flow behaviors. The apatite forming ability was investigated using X-ray diffraction and field emission scanning electron microscopy under secondary electron mode after immersion of samples in simulated body fluid (SBF) for time durations varying between 12 h and 7 days. The results obtained revealed that in spite of the good adhesion of glycerol and PEG carriers to glass particles during preparation stage, they did not hinder the exposure of bioactive glass particulates to the direct contact with SBF solution. The results confirmed the excellent bioactivity in vitro for all compositions expressed by high biomineralization rates with the formation of crystalline hydroxyapatite being identified by XRD after 12 h of immersion in SBF solution.

Item Type: Article
Erschienen: 2015
Creators: Tulyaganov, D. U. and Reddy, A. A. and Siegel, R. and Ionescu, E. and Riedel, R. and Ferreira, J. M. F.
Title: Synthesis and in vitro bioactivity assessment of injectable bioglass−organic pastes for bone tissue repair
Language: English
Abstract:

The aim of this work was to study the bioactivity of systems based on a clinically tested bioactive glass (BG) particulates (mol%: 4.33 Na2O−30.30 CaO−12.99 MgO−45.45 SiO2−2.60 P2O5−4.33 CaF2) and organic carriers. The cohesiveness of injectable bone graft products is of high relevance when filling complex volumetric bone defects. With this motivation behind, BG particulates with mean sizes within 11−14 μm were mixed in different proportions with glycerol (G) and polyethylene glycol (PEG) as organic carriers and the mixtures were fully injectable exhibiting Newtonian flow behaviors. The apatite forming ability was investigated using X-ray diffraction and field emission scanning electron microscopy under secondary electron mode after immersion of samples in simulated body fluid (SBF) for time durations varying between 12 h and 7 days. The results obtained revealed that in spite of the good adhesion of glycerol and PEG carriers to glass particles during preparation stage, they did not hinder the exposure of bioactive glass particulates to the direct contact with SBF solution. The results confirmed the excellent bioactivity in vitro for all compositions expressed by high biomineralization rates with the formation of crystalline hydroxyapatite being identified by XRD after 12 h of immersion in SBF solution.

Journal or Publication Title: Ceramics International
Volume: 41
Number: 8
Uncontrolled Keywords: Bioactive glasses, Organic carriers, XRD, SEM, Bone grafts
Divisions: 11 Department of Materials and Earth Sciences > Material Science > Dispersive Solids
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences
Date Deposited: 22 Jun 2015 11:01
Official URL: http://dx.doi.org/10.1016/j.ceramint.2015.03.312
Identification Number: doi:10.1016/j.ceramint.2015.03.312
Funders: The first author acknowledges financial support from the German Academic Exchange Service (DAAD organization)., A. A. Reddy is indebted to the Portuguese Foundation for Science and Technology (FCT) for the PhD Grant References SFRH/BD/89915/2012.
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