Wallhäusser-Franke, Elisabeth ; Braun, S. ; Langner, Gerald (1996)
Salicylate alters 2-DG uptake in the auditory system: a model for tinnitus?
In: Neuroreport, 7 (10)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Because salicylate is known to produce tinnitus in humans and animals, the effect of salicylate on the auditory system of gerbils was investigated using [14C]2-deoxyglucose (2-DG). Salicylate treatment reduced activity in the inferior colliculus (IC), particularly in the high frequency part, whereas activation along some isofrequency contours was observed in auditory cortex. In contrast, in saline-treated controls the IC but not the auditory cortex was active. These results suggest that the sensation of subjective tinnitus may be generated within auditory brain structures. The 2-DG method may be used to measure tinnitus objectively in animals and also to evaluate tinnitus treatments.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 1996 |
| Autor(en): | Wallhäusser-Franke, Elisabeth ; Braun, S. ; Langner, Gerald |
| Art des Eintrags: | Bibliographie |
| Titel: | Salicylate alters 2-DG uptake in the auditory system: a model for tinnitus? |
| Sprache: | Englisch |
| Publikationsjahr: | 1996 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Neuroreport |
| Jahrgang/Volume einer Zeitschrift: | 7 |
| (Heft-)Nummer: | 10 |
| Kurzbeschreibung (Abstract): | Because salicylate is known to produce tinnitus in humans and animals, the effect of salicylate on the auditory system of gerbils was investigated using [14C]2-deoxyglucose (2-DG). Salicylate treatment reduced activity in the inferior colliculus (IC), particularly in the high frequency part, whereas activation along some isofrequency contours was observed in auditory cortex. In contrast, in saline-treated controls the IC but not the auditory cortex was active. These results suggest that the sensation of subjective tinnitus may be generated within auditory brain structures. The 2-DG method may be used to measure tinnitus objectively in animals and also to evaluate tinnitus treatments. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie |
| Hinterlegungsdatum: | 11 Mai 2015 12:32 |
| Letzte Änderung: | 11 Mai 2015 12:32 |
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