TU Darmstadt / ULB / TUbiblio

Planning studies for a non-invasive treatment of atrial fibrillation with scanned ion beams

Constantinescu, Anna Maria (2014):
Planning studies for a non-invasive treatment of atrial fibrillation with scanned ion beams.
TU Darmstadt, [Online-Edition: http://tuprints.ulb.tu-darmstadt.de/4217],
[Ph.D. Thesis]

Abstract

One treatment modality for atrial fibrillation, the most common cardiac arrhythmia, is radiofrequency catheter ablation in which fibrotic tissue is created around the pulmonary veins. The procedure has major drawbacks, hence a new treatment modality would be beneficial. This is the first in silico study for the feasibility of a non-invasive treatment of atrial fibrillation with scanned ion beams, which are successfully used in cancer radiotherapy. In collaboration with the Mayo Clinic (Rochester, Minnesota, USA) the first comparison between different irradiation techniques to cardiac target volumes was carried out in this work. In the presented results it was shown that the dose deposition to organs at risk could be drastically reduced compared to a potential non-invasive treatment of atrial fibrillation with photons. As a result of the actively applied ion beam, interference effects were observed when irradiating the moving cardiac volumes. The motion influences of respiration and heartbeat were studied individually and the resulting displacement was examined. To achieve a homogenous dose deposition in the moving target volumes, motion mitigation techniques (gating and rescanning) were successfully applied. The results will be validated in animal experiments at GSI in 2014.

Item Type: Ph.D. Thesis
Erschienen: 2014
Creators: Constantinescu, Anna Maria
Title: Planning studies for a non-invasive treatment of atrial fibrillation with scanned ion beams
Language: English
Abstract:

One treatment modality for atrial fibrillation, the most common cardiac arrhythmia, is radiofrequency catheter ablation in which fibrotic tissue is created around the pulmonary veins. The procedure has major drawbacks, hence a new treatment modality would be beneficial. This is the first in silico study for the feasibility of a non-invasive treatment of atrial fibrillation with scanned ion beams, which are successfully used in cancer radiotherapy. In collaboration with the Mayo Clinic (Rochester, Minnesota, USA) the first comparison between different irradiation techniques to cardiac target volumes was carried out in this work. In the presented results it was shown that the dose deposition to organs at risk could be drastically reduced compared to a potential non-invasive treatment of atrial fibrillation with photons. As a result of the actively applied ion beam, interference effects were observed when irradiating the moving cardiac volumes. The motion influences of respiration and heartbeat were studied individually and the resulting displacement was examined. To achieve a homogenous dose deposition in the moving target volumes, motion mitigation techniques (gating and rescanning) were successfully applied. The results will be validated in animal experiments at GSI in 2014.

Divisions: 05 Department of Physics > Institute for condensed matter physics > Bio Physics
05 Department of Physics > Institute for condensed matter physics
05 Department of Physics
Date Deposited: 02 Nov 2014 20:55
Official URL: http://tuprints.ulb.tu-darmstadt.de/4217
URN: urn:nbn:de:tuda-tuprints-42177
Referees: Durante, Prof. Dr. Marco and Bert, Prof. Dr. Christoph
Refereed / Verteidigung / mdl. Prüfung: 25 April 2014
Alternative Abstract:
Alternative abstract Language
Eine Behandlungsmöglichkeit für Vorhofflimmern, der verbreitetsten Art von Herzrhythmusstörungen, ist Radiofrequenzablation mit Hilfe von Kathetern, bei der Narbengewebe um die Pulmonarvenen erzeugt wird. Dieser Eingriff hat schwerwiegenden Nachteile, so dass eine neue Behandlungsmöglichkeit wünschenswert wäre. Dies ist die erste in silico Studie, die die Durchführbarkeit einer nicht-invasive Behandlungsmöglichkeit für Vorhofflimmern mit gescannten Ionenstrahlen untersucht. Diese werden erfolgreich in der Strahlentherapie von Tumoren eingesetzt. In dieser Arbeit wurde in Kollaboration mit der Mayo Clinic (Rochester, Minnesota, USA) der erste Vergleich zwischen verschiedenen Bestrahlungsarten von Zielvolumina im Herzen durchgeführt. In den Ergebnissen konnte gezeigt werden, dass die Dosisbelastung der umliegenden Risikoorgane im Vergleich zu einer potentiellen nicht-invasiven Behandlung von Vorhofflimmern mit Photonen drastisch reduziert werden konnte. Aufgrund des aktiv applizierten Ionenstrahls wurden Interferenzeffekte bei der Bestrahlung bewegter Herzvolumina beobachtet. Der Bewegungseinfluss von Atmung und Herzschlag wurden unabhängig voneinander untersucht und die resultierende Auslenkung erforscht. Um eine homogene Dosis in den bewegten Zielvolumen zu erreichen wurden bewegungskompensierende Methoden (gating und rescanning) erfolgreich angewandt. Die Ergebnisse sollen in Tierstudien, die 2014 an der GSI durchgeführt werden, validiert werden. 1German
Export:

Optionen (nur für Redakteure)

View Item View Item