Ratajczyk, T. ; Gutmann, T. ; Dillenberger, S. ; Abdulhussaein, S. ; Frydel, J. ; Breitzke, H. ; Bommerich, U. ; Trantzschel, T. ; Bernarding, J. ; Magusin, P. C. M. M. ; Buntkowsky, G. (2012)
Time domain para hydrogen induced polarization.
In: Solid State Nuclear Magnetic Resonance, 43-44
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Para hydrogen induced polarization (PHIP) is a powerful hyperpolarization technique, which increases the NMR sensitivity by several orders of magnitude. However the hyperpolarized signal is created as an anti-phase signal, which necessitates high magnetic field homogeneity and spectral resolution in the conventional PHIP schemes. This hampers the application of PHIP enhancement in many fields, as for example in food science, materials science or MRI, where low B-0-fields or low B-0-homogeneity do decrease spectral resolution, leading to potential extinction if in-phase and anti-phase hyperpolarization signals cannot be resolved. Herein, we demonstrate that the echo sequence (45 degrees-tau-180 degrees-tau) enables the acquisition of low resolution PHIP enhanced liquid state NMR signals of phenylpropiolic acid derivatives and phenylacetylene at a low cost low-resolution 0.54 T spectrometer. As low field TD-spectrometers are commonly used in industry or biomedicine for the relaxometry of oil-water mixtures, food, nano-particles, or other systems, we compare two variants of para-hydrogen induced polarization with data-evaluation in the time domain (TD-PHIP). In both TD-ALTADENA and the TD-PASADENA strong spin echoes could be detected under conditions when usually no anti-phase signals can be measured due to the lack of resolution. The results suggest that the time-domain detection of PHIP-enhanced signals opens up new application areas for low-field PHIP-hyperpolarization, such as non-invasive compound detection or new contrast agents and biomarkers in low-field Magnetic Resonance Imaging (MRI). Finally, solid-state NMR calculations are presented, which show that the solid echo (90y-tau-90x-tau) version of the TD-ALTADENA experiment is able to convert up to 10 of the PHIP signal into visible magnetization. (C) 2012 Elsevier Inc. All rights reserved.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2012 |
| Autor(en): | Ratajczyk, T. ; Gutmann, T. ; Dillenberger, S. ; Abdulhussaein, S. ; Frydel, J. ; Breitzke, H. ; Bommerich, U. ; Trantzschel, T. ; Bernarding, J. ; Magusin, P. C. M. M. ; Buntkowsky, G. |
| Art des Eintrags: | Bibliographie |
| Titel: | Time domain para hydrogen induced polarization |
| Sprache: | Englisch |
| Publikationsjahr: | 2012 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Solid State Nuclear Magnetic Resonance |
| Jahrgang/Volume einer Zeitschrift: | 43-44 |
| URL / URN: | http://apps.webofknowledge.com/full_record.do?product=WOS&se... |
| Kurzbeschreibung (Abstract): | Para hydrogen induced polarization (PHIP) is a powerful hyperpolarization technique, which increases the NMR sensitivity by several orders of magnitude. However the hyperpolarized signal is created as an anti-phase signal, which necessitates high magnetic field homogeneity and spectral resolution in the conventional PHIP schemes. This hampers the application of PHIP enhancement in many fields, as for example in food science, materials science or MRI, where low B-0-fields or low B-0-homogeneity do decrease spectral resolution, leading to potential extinction if in-phase and anti-phase hyperpolarization signals cannot be resolved. Herein, we demonstrate that the echo sequence (45 degrees-tau-180 degrees-tau) enables the acquisition of low resolution PHIP enhanced liquid state NMR signals of phenylpropiolic acid derivatives and phenylacetylene at a low cost low-resolution 0.54 T spectrometer. As low field TD-spectrometers are commonly used in industry or biomedicine for the relaxometry of oil-water mixtures, food, nano-particles, or other systems, we compare two variants of para-hydrogen induced polarization with data-evaluation in the time domain (TD-PHIP). In both TD-ALTADENA and the TD-PASADENA strong spin echoes could be detected under conditions when usually no anti-phase signals can be measured due to the lack of resolution. The results suggest that the time-domain detection of PHIP-enhanced signals opens up new application areas for low-field PHIP-hyperpolarization, such as non-invasive compound detection or new contrast agents and biomarkers in low-field Magnetic Resonance Imaging (MRI). Finally, solid-state NMR calculations are presented, which show that the solid echo (90y-tau-90x-tau) version of the TD-ALTADENA experiment is able to convert up to 10 of the PHIP signal into visible magnetization. (C) 2012 Elsevier Inc. All rights reserved. |
| Freie Schlagworte: | nmr liquid state nmr para hydrogen induced polarization (phip) nmr signal enhancement time domain nmr spectrometer low field nmr solid-state nmr catalysis parahydrogen-induced polarization nuclear-magnetic-resonance c-13 hyperpolarization spin polarization contrast agents nmr field spectroscopy molecules sensitivity |
| Zusätzliche Informationen: | 948NF Times Cited:8 Cited References Count:49 |
| Fachbereich(e)/-gebiet(e): | 07 Fachbereich Chemie 07 Fachbereich Chemie > Eduard Zintl-Institut > Fachgebiet Physikalische Chemie |
| Hinterlegungsdatum: | 27 Okt 2014 20:47 |
| Letzte Änderung: | 29 Mai 2019 11:28 |
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