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Parahydrogen-Induced Polarization Transfer to F-19 in Perfluorocarbons for F-19 NMR Spectroscopy and MRI

Plaumann, M. and Bommerich, U. and Trantzschel, T. and Lego, D. and Dillenberger, S. and Sauer, G. and Bargon, J. and Buntkowsky, G. and Bernarding, J. (2013):
Parahydrogen-Induced Polarization Transfer to F-19 in Perfluorocarbons for F-19 NMR Spectroscopy and MRI.
In: Chemistry-a European Journal, 19 (20), pp. 6334-6339. [Article]

Abstract

Fluorinated substances are important in chemistry, industry, and the life sciences. In a new approach, parahydrogen-induced polarization (PHIP) is applied to enhance 19FMR signals of (perfluoro-n-hexyl)ethene and (perfluoro-n-hexyl)ethane. Unexpectedly, the end-standing CF3 group exhibits the highest amount of polarization despite the negligible coupling to the added protons. To clarify this non-intuitive distribution of polarization, signal enhancements in deuterated chloroform and acetone were compared and 19F19FNOESY spectra, as well as 19F T1 values were measured by NMR spectroscopy. By using the well separated and enhanced signal of the CF3 group, first 19FMR images of hyperpolarized linear semifluorinated alkenes were recorded.

Item Type: Article
Erschienen: 2013
Creators: Plaumann, M. and Bommerich, U. and Trantzschel, T. and Lego, D. and Dillenberger, S. and Sauer, G. and Bargon, J. and Buntkowsky, G. and Bernarding, J.
Title: Parahydrogen-Induced Polarization Transfer to F-19 in Perfluorocarbons for F-19 NMR Spectroscopy and MRI
Language: English
Abstract:

Fluorinated substances are important in chemistry, industry, and the life sciences. In a new approach, parahydrogen-induced polarization (PHIP) is applied to enhance 19FMR signals of (perfluoro-n-hexyl)ethene and (perfluoro-n-hexyl)ethane. Unexpectedly, the end-standing CF3 group exhibits the highest amount of polarization despite the negligible coupling to the added protons. To clarify this non-intuitive distribution of polarization, signal enhancements in deuterated chloroform and acetone were compared and 19F19FNOESY spectra, as well as 19F T1 values were measured by NMR spectroscopy. By using the well separated and enhanced signal of the CF3 group, first 19FMR images of hyperpolarized linear semifluorinated alkenes were recorded.

Journal or Publication Title: Chemistry-a European Journal
Journal volume: 19
Number: 20
Uncontrolled Keywords: fluorine hydrogenation imaging agents nmr spectroscopy polarization transfer magnetic-resonance para-hydrogen c-13 hyperpolarization enhancement metabolism alignment spectra agents noesy
Divisions: 07 Department of Chemistry
07 Department of Chemistry > Physical Chemistry
Date Deposited: 27 Oct 2014 20:47
Official URL: http://apps.webofknowledge.com/full_record.do?product=WOS&se...
Additional Information:

136ME Times Cited:6 Cited References Count:42

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