Plaumann, M. ; Bommerich, U. ; Trantzschel, T. ; Lego, D. ; Dillenberger, S. ; Sauer, G. ; Bargon, J. ; Buntkowsky, G. ; Bernarding, J. (2013)
Parahydrogen-Induced Polarization Transfer to F-19 in Perfluorocarbons for F-19 NMR Spectroscopy and MRI.
In: Chemistry-a European Journal, 19 (20)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Fluorinated substances are important in chemistry, industry, and the life sciences. In a new approach, parahydrogen-induced polarization (PHIP) is applied to enhance 19FMR signals of (perfluoro-n-hexyl)ethene and (perfluoro-n-hexyl)ethane. Unexpectedly, the end-standing CF3 group exhibits the highest amount of polarization despite the negligible coupling to the added protons. To clarify this non-intuitive distribution of polarization, signal enhancements in deuterated chloroform and acetone were compared and 19F19FNOESY spectra, as well as 19F T1 values were measured by NMR spectroscopy. By using the well separated and enhanced signal of the CF3 group, first 19FMR images of hyperpolarized linear semifluorinated alkenes were recorded.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2013 |
| Autor(en): | Plaumann, M. ; Bommerich, U. ; Trantzschel, T. ; Lego, D. ; Dillenberger, S. ; Sauer, G. ; Bargon, J. ; Buntkowsky, G. ; Bernarding, J. |
| Art des Eintrags: | Bibliographie |
| Titel: | Parahydrogen-Induced Polarization Transfer to F-19 in Perfluorocarbons for F-19 NMR Spectroscopy and MRI |
| Sprache: | Englisch |
| Publikationsjahr: | 2013 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Chemistry-a European Journal |
| Jahrgang/Volume einer Zeitschrift: | 19 |
| (Heft-)Nummer: | 20 |
| URL / URN: | http://apps.webofknowledge.com/full_record.do?product=WOS&se... |
| Kurzbeschreibung (Abstract): | Fluorinated substances are important in chemistry, industry, and the life sciences. In a new approach, parahydrogen-induced polarization (PHIP) is applied to enhance 19FMR signals of (perfluoro-n-hexyl)ethene and (perfluoro-n-hexyl)ethane. Unexpectedly, the end-standing CF3 group exhibits the highest amount of polarization despite the negligible coupling to the added protons. To clarify this non-intuitive distribution of polarization, signal enhancements in deuterated chloroform and acetone were compared and 19F19FNOESY spectra, as well as 19F T1 values were measured by NMR spectroscopy. By using the well separated and enhanced signal of the CF3 group, first 19FMR images of hyperpolarized linear semifluorinated alkenes were recorded. |
| Freie Schlagworte: | fluorine hydrogenation imaging agents nmr spectroscopy polarization transfer magnetic-resonance para-hydrogen c-13 hyperpolarization enhancement metabolism alignment spectra agents noesy |
| Zusätzliche Informationen: | 136ME Times Cited:6 Cited References Count:42 |
| Fachbereich(e)/-gebiet(e): | 07 Fachbereich Chemie 07 Fachbereich Chemie > Eduard Zintl-Institut > Fachgebiet Physikalische Chemie |
| Hinterlegungsdatum: | 27 Okt 2014 20:47 |
| Letzte Änderung: | 29 Mai 2019 11:00 |
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