Braun, Christian ; Schroeder, Indra ; Henkes, Leonhard M. ; Arrigoni, Cristina ; Kast, Stefan M. ; Moroni, Anna ; Thiel, Gerhard (2013)
Minimal viral K plus channels as robust model systems for understanding structure/function correlations.
In: European biophysics journal : EBJ, 42 (Suppl. 1)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
The channel proteins from Chlorella viruses are miniature versions of K+ channels; in essence they represent the pore module of complex K+ channels from eukaryotes. The combination of small size and robust function makes them good model systems for understanding basic structure/function correlates in K+ channels. The channel Kcv NTS counts only 82 amino acids per monomer and molecular dynamics simulations suggest that the channel is quasi fully embedded in the membrane bilayer. The intimate interaction between the channel protein and the surrounding bilayer offers the possibility to examine the performance of the channel in different experimental systems. We therefore performed single channel experiments in vertical and horizontal lipid bilayers as well in the membrane of native HEK-cellsystem. Furthermore we monitored channel conductance and gating in lipids with different head-groups and/or lipids with fatty acid chains of different length.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2013 |
| Autor(en): | Braun, Christian ; Schroeder, Indra ; Henkes, Leonhard M. ; Arrigoni, Cristina ; Kast, Stefan M. ; Moroni, Anna ; Thiel, Gerhard |
| Art des Eintrags: | Bibliographie |
| Titel: | Minimal viral K plus channels as robust model systems for understanding structure/function correlations |
| Sprache: | Englisch |
| Publikationsjahr: | 2013 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | European biophysics journal : EBJ |
| Jahrgang/Volume einer Zeitschrift: | 42 |
| (Heft-)Nummer: | Suppl. 1 |
| Kurzbeschreibung (Abstract): | The channel proteins from Chlorella viruses are miniature versions of K+ channels; in essence they represent the pore module of complex K+ channels from eukaryotes. The combination of small size and robust function makes them good model systems for understanding basic structure/function correlates in K+ channels. The channel Kcv NTS counts only 82 amino acids per monomer and molecular dynamics simulations suggest that the channel is quasi fully embedded in the membrane bilayer. The intimate interaction between the channel protein and the surrounding bilayer offers the possibility to examine the performance of the channel in different experimental systems. We therefore performed single channel experiments in vertical and horizontal lipid bilayers as well in the membrane of native HEK-cellsystem. Furthermore we monitored channel conductance and gating in lipids with different head-groups and/or lipids with fatty acid chains of different length. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Plant Membrane Biophyscis (am 20.12.23 umbenannt in Biologie der Algen und Protozoen) |
| Hinterlegungsdatum: | 01 Jul 2014 08:23 |
| Letzte Änderung: | 01 Jul 2014 08:34 |
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