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Under-approximating cut sets for reachability in large scale automata Networks

Paulevé, L. and Andrieux, G. and Koeppl, H. (2013):
Under-approximating cut sets for reachability in large scale automata Networks.
Springer, In: 25th International Conference on Computer Aided Verification (CAV 2013), [Online-Edition: http://link.springer.com/chapter/10.1007%2F978-3-642-39799-8...],
[Conference or Workshop Item]

Abstract

In the scope of discrete finite-state models of interacting components, we present a novel algorithm for identifying sets of local states of components whose activity is necessary for the reachability of a given local state. If all the local states from such a set are disabled in the model, the concerned reachability is impossible.</br>Those sets are referred to as cut sets and are computed from a particular abstract causality structure, so-called Graph of Local Causality, inspired from previous work and generalised here to finite automata networks. The extracted sets of local states form an under-approximation of the complete minimal cut sets of the dynamics: there may exist smaller or additional cut sets for the given reachability.</br>Applied to qualitative models of biological systems, such cut sets provide potential therapeutic targets that are proven to prevent molecules of interest to become active, up to the correctness of the model. Our new method makes tractable the formal analysis of very large scale networks, as illustrated by the computation of cut sets within a Boolean model of biological pathways interactions gathering more than 9000 components.

Item Type: Conference or Workshop Item
Erschienen: 2013
Creators: Paulevé, L. and Andrieux, G. and Koeppl, H.
Title: Under-approximating cut sets for reachability in large scale automata Networks
Language: English
Abstract:

In the scope of discrete finite-state models of interacting components, we present a novel algorithm for identifying sets of local states of components whose activity is necessary for the reachability of a given local state. If all the local states from such a set are disabled in the model, the concerned reachability is impossible.</br>Those sets are referred to as cut sets and are computed from a particular abstract causality structure, so-called Graph of Local Causality, inspired from previous work and generalised here to finite automata networks. The extracted sets of local states form an under-approximation of the complete minimal cut sets of the dynamics: there may exist smaller or additional cut sets for the given reachability.</br>Applied to qualitative models of biological systems, such cut sets provide potential therapeutic targets that are proven to prevent molecules of interest to become active, up to the correctness of the model. Our new method makes tractable the formal analysis of very large scale networks, as illustrated by the computation of cut sets within a Boolean model of biological pathways interactions gathering more than 9000 components.

Volume: 8044
Publisher: Springer
Divisions: 18 Department of Electrical Engineering and Information Technology > Institute for Telecommunications > Bioinspired Communication Systems
18 Department of Electrical Engineering and Information Technology
18 Department of Electrical Engineering and Information Technology > Institute for Telecommunications
Event Title: 25th International Conference on Computer Aided Verification (CAV 2013)
Date Deposited: 04 Apr 2014 12:22
Official URL: http://link.springer.com/chapter/10.1007%2F978-3-642-39799-8...
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