Lu, J. ; August, E. ; Koeppl, H. (2013)
Inverse problems from biomedicine : Inference of putative disease mechanisms and robust therapeutic strategies.
In: Journal of mathematical biology, 67 (1)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Many complex diseases that are difficult to treat cannot be mapped onto a single cause, but arise from the interplay of multiple contributing factors. In the study of such diseases, it is becoming apparent that therapeutic strategies targeting a single protein or metabolite are often not efficacious. Rather, a systems perspective describing the interaction of physiological components is needed. In this paper, we demonstrate via examples of disease models the kind of inverse problems that arise from the need to infer disease mechanisms and/or therapeutic strategies. We identify the challenges that arise, in particular the need to devise strategies that are robust against variable physiological states and parametric uncertainties.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2013 |
| Autor(en): | Lu, J. ; August, E. ; Koeppl, H. |
| Art des Eintrags: | Bibliographie |
| Titel: | Inverse problems from biomedicine : Inference of putative disease mechanisms and robust therapeutic strategies |
| Sprache: | Englisch |
| Publikationsjahr: | Juli 2013 |
| Verlag: | Springer Verlag |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Journal of mathematical biology |
| Jahrgang/Volume einer Zeitschrift: | 67 |
| (Heft-)Nummer: | 1 |
| URL / URN: | http://link.springer.com/article/10.1007/s00285-012-0523-z |
| Kurzbeschreibung (Abstract): | Many complex diseases that are difficult to treat cannot be mapped onto a single cause, but arise from the interplay of multiple contributing factors. In the study of such diseases, it is becoming apparent that therapeutic strategies targeting a single protein or metabolite are often not efficacious. Rather, a systems perspective describing the interaction of physiological components is needed. In this paper, we demonstrate via examples of disease models the kind of inverse problems that arise from the need to infer disease mechanisms and/or therapeutic strategies. We identify the challenges that arise, in particular the need to devise strategies that are robust against variable physiological states and parametric uncertainties. |
| Freie Schlagworte: | Biological, Cushing Syndrome, Cushing Syndrome: etiology, Cushing Syndrome: physiopathology, Disease, Disease: etiology, Epidermal Growth Factor,Epidermal Growth Factor: genetics,Epidermal Growth Factor: metabolism,Humans,Hypothalamo-Hypophyseal System,Hypothalamo-Hypophyseal System: physiopathology,Lipoproteins,Lipoproteins: metabolism,MAP Kinase Signaling System,Mathematical Concepts,Models,Mutation,Pituitary-Adrenal System,Pituitary-Adrenal System: physiopathology,Receptor,Systems Biology,Therapeutics,Therapeutics: statistics & numerical data |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik > Bioinspirierte Kommunikationssysteme 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik |
| Hinterlegungsdatum: | 04 Apr 2014 12:23 |
| Letzte Änderung: | 24 Jul 2023 12:56 |
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