Koeppl, H. ; Andreozzi, S. ; Steuer, R. (2011)
Guaranteed and Randomized Methods for Stability Analysis of Uncertain Metabolic Networks.
In: Lecture notes in control and information sciences, 407
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
A persistent problem hampering our understanding of the dynamics of large-scale metabolic networks is the lack of experimentally determined kinetic parameters that are necessary to build computationalmodels of biochemical processes. To overcome some of the limitations imposed by absent or incomplete kinetic data, structural kinetic modeling (SKM) was proposed recently as an intermediate approach between stoichiometric analysis and a full kinetic description. SKM extends stationary flux-balance analysis (FBA) by a local stability analysis utilizing an appropriate parametrization of the Jacobian matrix. To characterize the Jacobian, we utilize results from robust control theory to determine subintervals of the Jacobian’ entries that correspond to asymptotically stable metabolic states. Furthermore, we propose an efficient sampling scheme in combination with methods from computational geometry to sketch the stability region. A glycolytic pathway model comprising 12 uncertain parameters is used to assess the feasibility of the method.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2011 |
| Autor(en): | Koeppl, H. ; Andreozzi, S. ; Steuer, R. |
| Art des Eintrags: | Bibliographie |
| Titel: | Guaranteed and Randomized Methods for Stability Analysis of Uncertain Metabolic Networks |
| Sprache: | Englisch |
| Publikationsjahr: | 2011 |
| Verlag: | Springer |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Lecture notes in control and information sciences |
| Jahrgang/Volume einer Zeitschrift: | 407 |
| URL / URN: | http://link.springer.com/chapter/10.1007/978-3-642-16135-3_2... |
| Kurzbeschreibung (Abstract): | A persistent problem hampering our understanding of the dynamics of large-scale metabolic networks is the lack of experimentally determined kinetic parameters that are necessary to build computationalmodels of biochemical processes. To overcome some of the limitations imposed by absent or incomplete kinetic data, structural kinetic modeling (SKM) was proposed recently as an intermediate approach between stoichiometric analysis and a full kinetic description. SKM extends stationary flux-balance analysis (FBA) by a local stability analysis utilizing an appropriate parametrization of the Jacobian matrix. To characterize the Jacobian, we utilize results from robust control theory to determine subintervals of the Jacobian’ entries that correspond to asymptotically stable metabolic states. Furthermore, we propose an efficient sampling scheme in combination with methods from computational geometry to sketch the stability region. A glycolytic pathway model comprising 12 uncertain parameters is used to assess the feasibility of the method. |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik > Bioinspirierte Kommunikationssysteme 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik |
| Hinterlegungsdatum: | 04 Apr 2014 12:30 |
| Letzte Änderung: | 23 Sep 2021 14:32 |
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