Hafner, M. ; Koeppl, H. ; Gonze, D. (2012)
Effect of network architecture on synchronization and entrainment properties of the circadian oscillations in the suprachiasmatic nucleus.
In: PLoS computational biology, 8 (3)
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus constitutes the central circadian pacemaker. The SCN receives light signals from the retina and controls peripheral circadian clocks (located in the cortex, the pineal gland, the liver, the kidney, the heart, etc.). This hierarchical organization of the circadian system ensures the proper timing of physiological processes. In each SCN neuron, interconnected transcriptional and translational feedback loops enable the circadian expression of the clock genes. Although all the neurons have the same genotype, the oscillations of individual cells are highly heterogeneous in dispersed cell culture: many cells present damped oscillations and the period of the oscillations varies from cell to cell. In addition, the neurotransmitters that ensure the intercellular coupling, and thereby the synchronization of the cellular rhythms, differ between the two main regions of the SCN. In this work, a mathematical model that accounts for this heterogeneous organization of the SCN is presented and used to study the implication of the SCN network topology on synchronization and entrainment properties. The results show that oscillations with larger amplitude can be obtained with scale-free networks, in contrast to random and local connections. Networks with the small-world property such as the scale-free networks used in this work can adapt faster to a delay or advance in the light/dark cycle (jet lag). Interestingly a certain level of cellular heterogeneity is not detrimental to synchronization performances, but on the contrary helps resynchronization after jet lag. When coupling two networks with different topologies that mimic the two regions of the SCN, efficient filtering of pulse-like perturbations in the entrainment pattern is observed. These results suggest that the complex and heterogeneous architecture of the SCN decreases the sensitivity of the network to short entrainment perturbations while, at the same time, improving its adaptation abilities to long term changes.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2012 |
| Autor(en): | Hafner, M. ; Koeppl, H. ; Gonze, D. |
| Art des Eintrags: | Bibliographie |
| Titel: | Effect of network architecture on synchronization and entrainment properties of the circadian oscillations in the suprachiasmatic nucleus |
| Sprache: | Englisch |
| Publikationsjahr: | Januar 2012 |
| Ort: | San Francisco, Kalifornien, USA |
| Verlag: | PLOS |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | PLoS computational biology |
| Jahrgang/Volume einer Zeitschrift: | 8 |
| (Heft-)Nummer: | 3 |
| Kollation: | 16 Seiten |
| URL / URN: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297560/?tool=pm... |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus constitutes the central circadian pacemaker. The SCN receives light signals from the retina and controls peripheral circadian clocks (located in the cortex, the pineal gland, the liver, the kidney, the heart, etc.). This hierarchical organization of the circadian system ensures the proper timing of physiological processes. In each SCN neuron, interconnected transcriptional and translational feedback loops enable the circadian expression of the clock genes. Although all the neurons have the same genotype, the oscillations of individual cells are highly heterogeneous in dispersed cell culture: many cells present damped oscillations and the period of the oscillations varies from cell to cell. In addition, the neurotransmitters that ensure the intercellular coupling, and thereby the synchronization of the cellular rhythms, differ between the two main regions of the SCN. In this work, a mathematical model that accounts for this heterogeneous organization of the SCN is presented and used to study the implication of the SCN network topology on synchronization and entrainment properties. The results show that oscillations with larger amplitude can be obtained with scale-free networks, in contrast to random and local connections. Networks with the small-world property such as the scale-free networks used in this work can adapt faster to a delay or advance in the light/dark cycle (jet lag). Interestingly a certain level of cellular heterogeneity is not detrimental to synchronization performances, but on the contrary helps resynchronization after jet lag. When coupling two networks with different topologies that mimic the two regions of the SCN, efficient filtering of pulse-like perturbations in the entrainment pattern is observed. These results suggest that the complex and heterogeneous architecture of the SCN decreases the sensitivity of the network to short entrainment perturbations while, at the same time, improving its adaptation abilities to long term changes. |
| Freie Schlagworte: | Action Potentials, Action Potentials: physiology, Animals, Biological Clocks, Biological Clocks: physiology, Circadian Rhythm, Circadian Rhythm: physiology, Computer Simulation, Humans, Models, Nerve Net, Nerve Net: anatomy & histology, Nerve Net: physiology, Neurological, Neurons, Neurons: physiology, Suprachiasmatic Nucleus, Suprachiasmatic Nucleus: anatomy & histology, Suprachiasmatic Nucleus: physiology, Synaptic Transmission, Synaptic Transmission: physiology |
| ID-Nummer: | Artikel-ID: e1002419 |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik > Bioinspirierte Kommunikationssysteme 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik |
| Hinterlegungsdatum: | 04 Apr 2014 13:02 |
| Letzte Änderung: | 05 Sep 2024 09:34 |
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| Suche nach Titel in: | TUfind oder in Google |
Verfügbare Versionen dieses Eintrags
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Effect of Network Architecture on Synchronization and Entrainment Properties of the Circadian Oscillations in the Suprachiasmatic Nucleus. (deposited 13 Mai 2024 10:06)
- Effect of network architecture on synchronization and entrainment properties of the circadian oscillations in the suprachiasmatic nucleus. (deposited 04 Apr 2014 13:02) [Gegenwärtig angezeigt]
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