August, E. ; Koeppl, H. (2012)
Computing enclosures for uncertain biochemical systems.
In: IET Systems Biology, 6 (6)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
In this study, the authors present a novel method that provides enclosures for state trajectories of a non-linear dynamical system with uncertainties in initial conditions and parameter values. It is based on solving positivity conditions by means of semi-definite programmes and sum of squares decompositions. The method accounts for the indeterminacy of kinetic parameters, measurement uncertainties and fluctuations in the reaction rates because of extrinsic noise. This is particularly useful in the field of systems biology when one seeks to determine model behaviour quantitatively or, if this is not possible, semiquantitatively. The authors also demonstrate the significance of the proposed method to model selection in biology. The authors illustrate the applicability of their method on the mitogen-activated protein kinase signalling pathway, which is an important and reoccurring network motif that apparently also plays a crucial role in the development of cancer.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2012 |
| Autor(en): | August, E. ; Koeppl, H. |
| Art des Eintrags: | Bibliographie |
| Titel: | Computing enclosures for uncertain biochemical systems |
| Sprache: | Englisch |
| Publikationsjahr: | Dezember 2012 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | IET Systems Biology |
| Jahrgang/Volume einer Zeitschrift: | 6 |
| (Heft-)Nummer: | 6 |
| URL / URN: | http://digital-library.theiet.org/content/journals/10.1049/i... |
| Kurzbeschreibung (Abstract): | In this study, the authors present a novel method that provides enclosures for state trajectories of a non-linear dynamical system with uncertainties in initial conditions and parameter values. It is based on solving positivity conditions by means of semi-definite programmes and sum of squares decompositions. The method accounts for the indeterminacy of kinetic parameters, measurement uncertainties and fluctuations in the reaction rates because of extrinsic noise. This is particularly useful in the field of systems biology when one seeks to determine model behaviour quantitatively or, if this is not possible, semiquantitatively. The authors also demonstrate the significance of the proposed method to model selection in biology. The authors illustrate the applicability of their method on the mitogen-activated protein kinase signalling pathway, which is an important and reoccurring network motif that apparently also plays a crucial role in the development of cancer. |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik > Bioinspirierte Kommunikationssysteme 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik |
| Hinterlegungsdatum: | 04 Apr 2014 12:43 |
| Letzte Änderung: | 23 Sep 2021 14:31 |
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