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A novel Ti-based nanoglass composite with submicron–nanometer-sized hierarchical structures to modulate osteoblast behaviors

Chen, Na and Shi, Xuetao and Witte, Ralf and Nakayama, Koji S. and Ohmura, Kazuyo and Wu, Hongkai and Takeuchi, Akira and Hahn, Horst and Esashi, Masayoshi and Gleiter, Herbert and Inoue, Akihisa and Louzguine, Dmitri V. (2013):
A novel Ti-based nanoglass composite with submicron–nanometer-sized hierarchical structures to modulate osteoblast behaviors.
In: Journal of Materials Chemistry B, 1 (20), Royal Society of Chemistry Publishing, p. 2568, ISSN 2050-750X,
[Online-Edition: http://dx.doi.org/10.1039/C3TB20153H],
[Article]

Abstract

Owing to recent progress in nanotechnology, the ability to tune the surface properties of metals has opened an avenue for creating a new generation of biomaterials. Here we demonstrate the successful development of a novel Ti-based nanoglass composite with submicron–nanometer-sized hierarchical glassy structures. A first exploratory study was performed on the application of the unique nanostructure to modulate osteoblast behaviors. Our results show that this Ti-based nanoglass composite, relative to conventional metallic glasses, exhibits significantly improved biocompatibility. In fact, a 10 times enhancement in cell proliferation has been achieved. To a great extent, this superior bioactivity (such as enhanced cell proliferation and osteogenic phenotype) is promoted by its unique hierarchical structures combining nanoglobules and submicron button-like clusters from collective packing of these nanoglobules. This nanoglass composite could be widely applicable for surface modifications by means of coating on various materials including BMGs, crystalline metals or ceramics. Therefore, our successful experimental testing of this nanostructured metallic glass may open the way to new applications in novel biomaterial design for the purpose of bone replacement.

Item Type: Article
Erschienen: 2013
Creators: Chen, Na and Shi, Xuetao and Witte, Ralf and Nakayama, Koji S. and Ohmura, Kazuyo and Wu, Hongkai and Takeuchi, Akira and Hahn, Horst and Esashi, Masayoshi and Gleiter, Herbert and Inoue, Akihisa and Louzguine, Dmitri V.
Title: A novel Ti-based nanoglass composite with submicron–nanometer-sized hierarchical structures to modulate osteoblast behaviors
Language: English
Abstract:

Owing to recent progress in nanotechnology, the ability to tune the surface properties of metals has opened an avenue for creating a new generation of biomaterials. Here we demonstrate the successful development of a novel Ti-based nanoglass composite with submicron–nanometer-sized hierarchical glassy structures. A first exploratory study was performed on the application of the unique nanostructure to modulate osteoblast behaviors. Our results show that this Ti-based nanoglass composite, relative to conventional metallic glasses, exhibits significantly improved biocompatibility. In fact, a 10 times enhancement in cell proliferation has been achieved. To a great extent, this superior bioactivity (such as enhanced cell proliferation and osteogenic phenotype) is promoted by its unique hierarchical structures combining nanoglobules and submicron button-like clusters from collective packing of these nanoglobules. This nanoglass composite could be widely applicable for surface modifications by means of coating on various materials including BMGs, crystalline metals or ceramics. Therefore, our successful experimental testing of this nanostructured metallic glass may open the way to new applications in novel biomaterial design for the purpose of bone replacement.

Journal or Publication Title: Journal of Materials Chemistry B
Volume: 1
Number: 20
Publisher: Royal Society of Chemistry Publishing
Divisions: 11 Department of Materials and Earth Sciences > Material Science > Joint Research Laboratory Nanomaterials
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences
Date Deposited: 06 Feb 2014 09:23
Official URL: http://dx.doi.org/10.1039/C3TB20153H
Identification Number: doi:10.1039/C3TB20153H
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