Ochs, Meike J. ; Suess, Beatrix ; Steinhilber, Dieter (2014)
5-Lipoxygenase mRNA and Protein Isoforms.
In: Basic & clinical pharmacology & toxicology, 114 (1)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes, a group of inflammatory lipid mediators derived from arachidonic acid. An increased level of leukotrienes is associated with chronic inflammatory diseases like asthma or atherosclerosis. In this MiniReview, we focus on recent findings regarding alternative splice variants of 5-LO with a special emphasis on two potential protein isoforms expressed in human B-lymphocytes which might be of interest as new drug targets. This article is protected by copyright. All rights reserved.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2014 |
| Autor(en): | Ochs, Meike J. ; Suess, Beatrix ; Steinhilber, Dieter |
| Art des Eintrags: | Bibliographie |
| Titel: | 5-Lipoxygenase mRNA and Protein Isoforms. |
| Sprache: | Englisch |
| Publikationsjahr: | 2014 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Basic & clinical pharmacology & toxicology |
| Jahrgang/Volume einer Zeitschrift: | 114 |
| (Heft-)Nummer: | 1 |
| Kurzbeschreibung (Abstract): | 5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes, a group of inflammatory lipid mediators derived from arachidonic acid. An increased level of leukotrienes is associated with chronic inflammatory diseases like asthma or atherosclerosis. In this MiniReview, we focus on recent findings regarding alternative splice variants of 5-LO with a special emphasis on two potential protein isoforms expressed in human B-lymphocytes which might be of interest as new drug targets. This article is protected by copyright. All rights reserved. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Synthetic Genetic Circuits (2020 umbenannt in "Synthetic RNA biology") |
| Hinterlegungsdatum: | 18 Sep 2013 11:10 |
| Letzte Änderung: | 28 Jan 2014 12:38 |
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