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A straightforward synthesis of (3S)-4-methoxybutane-1,3-diol and its use as chiral auxiliary for the preparation of (pS)-1-(diphenylphosphino)-2-formyl-1 `,2 `,3 `,4 `,5 `-pentamethylferrocene

Geisler, Felix M. and Helmchen, Guenter (2006):
A straightforward synthesis of (3S)-4-methoxybutane-1,3-diol and its use as chiral auxiliary for the preparation of (pS)-1-(diphenylphosphino)-2-formyl-1 `,2 `,3 `,4 `,5 `-pentamethylferrocene.
In: SYNTHESIS-STUTTGART, pp. 2201-2205, (13), [Online-Edition: http://dx.doi.org/10.1055/s-2006-942415],
[Article]

Abstract

(3S)-4-Methoxy-butane-1,3-diol (S)-4, an important auxiliary for the synthesis of planar-chiral metallocenes, has been obtained from (S)-1,2,4-butanetriol via formation of an isomerically pure acetal of p-nitrobenzaldehyde, O-methylation and hydrolysis. Diol (S)-4 was used in a synthesis of the new planar-chiral ferrocene ({pS)-1-(diphenylphosphiiio)-2-formyl-1'},2',3',4',5'-pentamethylferrocene ({pS)-9.}

Item Type: Article
Erschienen: 2006
Creators: Geisler, Felix M. and Helmchen, Guenter
Title: A straightforward synthesis of (3S)-4-methoxybutane-1,3-diol and its use as chiral auxiliary for the preparation of (pS)-1-(diphenylphosphino)-2-formyl-1 `,2 `,3 `,4 `,5 `-pentamethylferrocene
Language: English
Abstract:

(3S)-4-Methoxy-butane-1,3-diol (S)-4, an important auxiliary for the synthesis of planar-chiral metallocenes, has been obtained from (S)-1,2,4-butanetriol via formation of an isomerically pure acetal of p-nitrobenzaldehyde, O-methylation and hydrolysis. Diol (S)-4 was used in a synthesis of the new planar-chiral ferrocene ({pS)-1-(diphenylphosphiiio)-2-formyl-1'},2',3',4',5'-pentamethylferrocene ({pS)-9.}

Journal or Publication Title: SYNTHESIS-STUTTGART
Number: 13
Divisions: Zentrale Einrichtungen > University and State Library Darmstadt (ULB)
Zentrale Einrichtungen
Date Deposited: 12 Sep 2013 12:05
Official URL: http://dx.doi.org/10.1055/s-2006-942415
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