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Potassium Ion Channels: Could They Have Evolved From Viruses?

Thiel, Gerhard and Moroni, Anna and Blanc, Guillaume and Vanetten, James L. (2013):
Potassium Ion Channels: Could They Have Evolved From Viruses?
In: Plant physiology, pp. 1215-1224, 162, (3), ISSN 1532-2548,
[Article]

Abstract

All potassium channels share a common architecture consisting of their pore module with two transmembrane domains and a conserved filter region that selects for K+ ions. The current view is that the plethora of complex K+ channels in eukaryotes evolved from a pore module precursor via gene fusions and gene duplications. Here we suggest that this pore precursor might have originated from viruses. This view is fostered by new ideas and insights into the role of viruses in evolution and by the discovery of viral K+ channels that were not acquired from their current algal hosts. These small virus encoded channel proteins resemble the postulated pore precursor. Furthermore, the structural and functional features of complex eukaryotic K+ channels can be formed by a few simple genetic manipulations.

Item Type: Article
Erschienen: 2013
Creators: Thiel, Gerhard and Moroni, Anna and Blanc, Guillaume and Vanetten, James L.
Title: Potassium Ion Channels: Could They Have Evolved From Viruses?
Language: English
Abstract:

All potassium channels share a common architecture consisting of their pore module with two transmembrane domains and a conserved filter region that selects for K+ ions. The current view is that the plethora of complex K+ channels in eukaryotes evolved from a pore module precursor via gene fusions and gene duplications. Here we suggest that this pore precursor might have originated from viruses. This view is fostered by new ideas and insights into the role of viruses in evolution and by the discovery of viral K+ channels that were not acquired from their current algal hosts. These small virus encoded channel proteins resemble the postulated pore precursor. Furthermore, the structural and functional features of complex eukaryotic K+ channels can be formed by a few simple genetic manipulations.

Journal or Publication Title: Plant physiology
Volume: 162
Number: 3
Divisions: 10 Department of Biology
10 Department of Biology > Plant Membrane Biophysics
Date Deposited: 25 Jun 2013 12:16
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