Thiel, Gerhard ; Moroni, Anna ; Blanc, Guillaume ; Vanetten, James L. (2013)
Potassium Ion Channels: Could They Have Evolved From Viruses?
In: Plant physiology, 162 (3)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
All potassium channels share a common architecture consisting of their pore module with two transmembrane domains and a conserved filter region that selects for K+ ions. The current view is that the plethora of complex K+ channels in eukaryotes evolved from a pore module precursor via gene fusions and gene duplications. Here we suggest that this pore precursor might have originated from viruses. This view is fostered by new ideas and insights into the role of viruses in evolution and by the discovery of viral K+ channels that were not acquired from their current algal hosts. These small virus encoded channel proteins resemble the postulated pore precursor. Furthermore, the structural and functional features of complex eukaryotic K+ channels can be formed by a few simple genetic manipulations.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2013 |
| Autor(en): | Thiel, Gerhard ; Moroni, Anna ; Blanc, Guillaume ; Vanetten, James L. |
| Art des Eintrags: | Bibliographie |
| Titel: | Potassium Ion Channels: Could They Have Evolved From Viruses? |
| Sprache: | Englisch |
| Publikationsjahr: | 2013 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Plant physiology |
| Jahrgang/Volume einer Zeitschrift: | 162 |
| (Heft-)Nummer: | 3 |
| Kurzbeschreibung (Abstract): | All potassium channels share a common architecture consisting of their pore module with two transmembrane domains and a conserved filter region that selects for K+ ions. The current view is that the plethora of complex K+ channels in eukaryotes evolved from a pore module precursor via gene fusions and gene duplications. Here we suggest that this pore precursor might have originated from viruses. This view is fostered by new ideas and insights into the role of viruses in evolution and by the discovery of viral K+ channels that were not acquired from their current algal hosts. These small virus encoded channel proteins resemble the postulated pore precursor. Furthermore, the structural and functional features of complex eukaryotic K+ channels can be formed by a few simple genetic manipulations. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Plant Membrane Biophyscis (am 20.12.23 umbenannt in Biologie der Algen und Protozoen) |
| Hinterlegungsdatum: | 25 Jun 2013 12:16 |
| Letzte Änderung: | 27 Aug 2013 11:44 |
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