TU Darmstadt / ULB / TUbiblio

The papain inhibitor (SPI) of Streptomyces mobaraensis inhibits bacterial cysteine proteases and is an antagonist of bacterial growth.

Zindel, Stephan and Kaman, Wendy E. and Fröls, Sabrina and Pfeifer, Felicitas and Peters, Anna and Hays, John P. and Fuchsbauer, Hans-Lothar (2013):
The papain inhibitor (SPI) of Streptomyces mobaraensis inhibits bacterial cysteine proteases and is an antagonist of bacterial growth.
In: Antimicrobial agents and chemotherapy, pp. 3388-3391, 57, (7), ISSN 1098-6596, [Article]

Abstract

A novel papain inhibitory protein (SPI) from Streptomyces mobaraensis was used to measure its inhibitory effect on bacterial cysteine protease activity (Staphylococcus aureus SspB) and culture supernatants (Porphyromonas gingivalis, Bacillus anthracis). Further, growth of Bacillus anthracis, Staphylococcus aureus, Pseudomonas aeruginosa, and Vibrio cholerae was completely inhibited by 10 μM SPI. At this concentration of SPI no cytotoxicity was observed. We conclude that SPI inhibits bacterial virulence factors and has the potential to become a novel therapeutic treatment against a range of unrelated pathogenic bacteria.

Item Type: Article
Erschienen: 2013
Creators: Zindel, Stephan and Kaman, Wendy E. and Fröls, Sabrina and Pfeifer, Felicitas and Peters, Anna and Hays, John P. and Fuchsbauer, Hans-Lothar
Title: The papain inhibitor (SPI) of Streptomyces mobaraensis inhibits bacterial cysteine proteases and is an antagonist of bacterial growth.
Language: English
Abstract:

A novel papain inhibitory protein (SPI) from Streptomyces mobaraensis was used to measure its inhibitory effect on bacterial cysteine protease activity (Staphylococcus aureus SspB) and culture supernatants (Porphyromonas gingivalis, Bacillus anthracis). Further, growth of Bacillus anthracis, Staphylococcus aureus, Pseudomonas aeruginosa, and Vibrio cholerae was completely inhibited by 10 μM SPI. At this concentration of SPI no cytotoxicity was observed. We conclude that SPI inhibits bacterial virulence factors and has the potential to become a novel therapeutic treatment against a range of unrelated pathogenic bacteria.

Journal or Publication Title: Antimicrobial agents and chemotherapy
Volume: 57
Number: 7
Divisions: 10 Department of Biology
10 Department of Biology > Microbiology and Archaea
Date Deposited: 23 Apr 2013 09:27
Export:

Optionen (nur für Redakteure)

View Item View Item