Zindel, Stephan ; Kaman, Wendy E. ; Fröls, Sabrina ; Pfeifer, Felicitas ; Peters, Anna ; Hays, John P. ; Fuchsbauer, Hans-Lothar (2013)
The papain inhibitor (SPI) of Streptomyces mobaraensis inhibits bacterial cysteine proteases and is an antagonist of bacterial growth.
In: Antimicrobial agents and chemotherapy, 57 (7)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
A novel papain inhibitory protein (SPI) from Streptomyces mobaraensis was used to measure its inhibitory effect on bacterial cysteine protease activity (Staphylococcus aureus SspB) and culture supernatants (Porphyromonas gingivalis, Bacillus anthracis). Further, growth of Bacillus anthracis, Staphylococcus aureus, Pseudomonas aeruginosa, and Vibrio cholerae was completely inhibited by 10 μM SPI. At this concentration of SPI no cytotoxicity was observed. We conclude that SPI inhibits bacterial virulence factors and has the potential to become a novel therapeutic treatment against a range of unrelated pathogenic bacteria.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2013 |
| Autor(en): | Zindel, Stephan ; Kaman, Wendy E. ; Fröls, Sabrina ; Pfeifer, Felicitas ; Peters, Anna ; Hays, John P. ; Fuchsbauer, Hans-Lothar |
| Art des Eintrags: | Bibliographie |
| Titel: | The papain inhibitor (SPI) of Streptomyces mobaraensis inhibits bacterial cysteine proteases and is an antagonist of bacterial growth. |
| Sprache: | Englisch |
| Publikationsjahr: | 2013 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Antimicrobial agents and chemotherapy |
| Jahrgang/Volume einer Zeitschrift: | 57 |
| (Heft-)Nummer: | 7 |
| Kurzbeschreibung (Abstract): | A novel papain inhibitory protein (SPI) from Streptomyces mobaraensis was used to measure its inhibitory effect on bacterial cysteine protease activity (Staphylococcus aureus SspB) and culture supernatants (Porphyromonas gingivalis, Bacillus anthracis). Further, growth of Bacillus anthracis, Staphylococcus aureus, Pseudomonas aeruginosa, and Vibrio cholerae was completely inhibited by 10 μM SPI. At this concentration of SPI no cytotoxicity was observed. We conclude that SPI inhibits bacterial virulence factors and has the potential to become a novel therapeutic treatment against a range of unrelated pathogenic bacteria. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Microbiology and Archaea |
| Hinterlegungsdatum: | 23 Apr 2013 09:27 |
| Letzte Änderung: | 27 Aug 2013 11:42 |
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