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Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates

Detsch, Rainer and Guillon, Olivier and Wondraczek, Lothar and Boccaccini, Aldo R. (2012):
Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates.
In: Advanced Engineering Materials, pp. B38-B44, 14, (3), ISSN 14381656, [Online-Edition: http://dx.doi.org/10.1002/adem.201180068],
[Article]

Abstract

A soft lithography technique was used to introduce surface patterns on the surface of sintered bioactive glass substrates. Osteoblast-like MG-63 cells and rat mesenchymal stem cells (rMSC) seeded on micropatterned bioactive glass surfaces showed different behavior with rMSC exhibiting a better initial attachment than MG-63 cells. Both cytoskeleton formation and cell spreading of rMSC were supported by the bioactive surfaces. In addition, the structured surfaces seemed to guide MG-63 cells to a larger extent than rMSC. The in vitro results are important considering the continuous development of bone tissue scaffolds based on silicate bioactive glasses.

Item Type: Article
Erschienen: 2012
Creators: Detsch, Rainer and Guillon, Olivier and Wondraczek, Lothar and Boccaccini, Aldo R.
Title: Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates
Language: English
Abstract:

A soft lithography technique was used to introduce surface patterns on the surface of sintered bioactive glass substrates. Osteoblast-like MG-63 cells and rat mesenchymal stem cells (rMSC) seeded on micropatterned bioactive glass surfaces showed different behavior with rMSC exhibiting a better initial attachment than MG-63 cells. Both cytoskeleton formation and cell spreading of rMSC were supported by the bioactive surfaces. In addition, the structured surfaces seemed to guide MG-63 cells to a larger extent than rMSC. The in vitro results are important considering the continuous development of bone tissue scaffolds based on silicate bioactive glasses.

Journal or Publication Title: Advanced Engineering Materials
Volume: 14
Number: 3
Divisions: 11 Department of Materials and Earth Sciences > Material Science > Nonmetallic-Inorganic Materials
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences
Date Deposited: 07 Jan 2013 13:06
Official URL: http://dx.doi.org/10.1002/adem.201180068
Identification Number: doi:10.1002/adem.201180068
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