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Fabrication of Nanochannel Arrays for the Selective Transport of Ionic Species

Nguyen, Q. H. and Ali, Mubarak and Nasir, Saima and Ensinger, Wolfgang Edel, J. and Albrecht, T. (eds.) (2012):
Fabrication of Nanochannel Arrays for the Selective Transport of Ionic Species.
In: Nanopores for Bioanalytical Applications: Proceedings of the International Conference, RSC Publishing, pp. 83-88, [Online-Edition: http://pubs.rsc.org/en/content/chapter/bk9781849734165-00083...],
[Book Section]

Abstract

In summary, we have described a direct and simple method to control the surface charge properties of ion-tracked PET membranes via carbodiimide coupling chemistry. We have demonstrated that the negatively charged membranes allow the selective transport of positively charged molecules and hinder the passage of negatively charged ones. The selectivity of these filters was reversed by changing the surface polarity from negative to positive via amination. We have also described here the construction of a system which demonstrates ATP-modulated molecular transport through synthetic nanochannels. The molecular flux is chemically controlled via ATP in the surrounding environment. In this context, we believe that this platform would be applicable for the discrimination of enantiomers of drug molecules and multi-responsive drug delivery system at the nanoscale level by introducing suitable functionalities on the channel surface.

Item Type: Book Section
Erschienen: 2012
Editors: Edel, J. and Albrecht, T.
Creators: Nguyen, Q. H. and Ali, Mubarak and Nasir, Saima and Ensinger, Wolfgang
Title: Fabrication of Nanochannel Arrays for the Selective Transport of Ionic Species
Language: English
Abstract:

In summary, we have described a direct and simple method to control the surface charge properties of ion-tracked PET membranes via carbodiimide coupling chemistry. We have demonstrated that the negatively charged membranes allow the selective transport of positively charged molecules and hinder the passage of negatively charged ones. The selectivity of these filters was reversed by changing the surface polarity from negative to positive via amination. We have also described here the construction of a system which demonstrates ATP-modulated molecular transport through synthetic nanochannels. The molecular flux is chemically controlled via ATP in the surrounding environment. In this context, we believe that this platform would be applicable for the discrimination of enantiomers of drug molecules and multi-responsive drug delivery system at the nanoscale level by introducing suitable functionalities on the channel surface.

Title of Book: Nanopores for Bioanalytical Applications: Proceedings of the International Conference
Publisher: RSC Publishing
ISBN: 978-1-84973-527-8
Divisions: 11 Department of Materials and Earth Sciences
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences > Material Science > Material Analytics
Date Deposited: 08 Oct 2012 12:38
Official URL: http://pubs.rsc.org/en/content/chapter/bk9781849734165-00083...
Additional Information:

This book focuses on bioanalytical applications in the multidisciplinary and growing field of nanopore research. Based on the proceedings of the 1st International Conference on Nanopores for Bioanalytical Applications (Lanzarote, 2012), it is suitable for readers in both academia and industry. It describes the latest experimental and fabrication protocols necessary to carry out nanopore-based experiments and covers a wide variety of topics. These include: ion transport; polymers in solution; translocation processes; electrophoresis and mobility; hydrodynamics; cell design; noise as an analytical tool; pore characterization; fabrication methods; DNA and RNA translocation; protein binding; DNA unzipping; sequence analysis, and molecular gating.

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