Hammann, Christian ; Luptak, Andrej ; Perreault, Jonathan ; Peña, Marcos de la (2012)
The ubiquitous hammerhead ribozyme.
In: RNA (New York, N.Y.), 18 (5)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
The hammerhead ribozyme is a small catalytic RNA motif capable of endonucleolytic (self-) cleavage. It is composed of a catalytic core of conserved nucleotides flanked by three helices, two of which form essential tertiary interactions for fast self-scission under physiological conditions. Originally discovered in subviral plant pathogens, its presence in several eukaryotic genomes has been reported since. More recently, this catalytic RNA motif has been shown to reside in a large number of genomes. We review the different approaches in discovering these new hammerhead ribozyme sequences and discuss possible biological functions of the genomic motifs.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2012 |
| Autor(en): | Hammann, Christian ; Luptak, Andrej ; Perreault, Jonathan ; Peña, Marcos de la |
| Art des Eintrags: | Bibliographie |
| Titel: | The ubiquitous hammerhead ribozyme |
| Sprache: | Englisch |
| Publikationsjahr: | 2012 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | RNA (New York, N.Y.) |
| Jahrgang/Volume einer Zeitschrift: | 18 |
| (Heft-)Nummer: | 5 |
| Kurzbeschreibung (Abstract): | The hammerhead ribozyme is a small catalytic RNA motif capable of endonucleolytic (self-) cleavage. It is composed of a catalytic core of conserved nucleotides flanked by three helices, two of which form essential tertiary interactions for fast self-scission under physiological conditions. Originally discovered in subviral plant pathogens, its presence in several eukaryotic genomes has been reported since. More recently, this catalytic RNA motif has been shown to reside in a large number of genomes. We review the different approaches in discovering these new hammerhead ribozyme sequences and discuss possible biological functions of the genomic motifs. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie ?? fb10_mikrobiologie ?? 10 Fachbereich Biologie > Regulatorische RNAs und Ribozyme |
| Hinterlegungsdatum: | 05 Apr 2012 08:43 |
| Letzte Änderung: | 20 Aug 2021 12:50 |
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