Arora, Amit ; Suess, Beatrix (2011)
An RNA G-quadruplex in the 3' UTR of the proto-oncogene PIM1 represses translation.
In: RNA biology, 8 (5)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
We have identified a conserved G-quadruplex forming sequence in the 3' untranslated region (UTR) of the proto-oncogene PIM1. Circular dichroism and thermal denaturation studies revealed that the PIM1 mRNA guanine-rich sequence forms a highly stable intramolecular G-quadruplex structure. Reporter gene assay demonstrated that the PIM1 RNA G-quadruplex represses translation. It is the first experimental evidence of an RNA G-quadruplex structure located in the 3' UTR that may act as posttranscriptional regulator.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2011 |
| Autor(en): | Arora, Amit ; Suess, Beatrix |
| Art des Eintrags: | Bibliographie |
| Titel: | An RNA G-quadruplex in the 3' UTR of the proto-oncogene PIM1 represses translation. |
| Sprache: | Englisch |
| Publikationsjahr: | 2011 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | RNA biology |
| Jahrgang/Volume einer Zeitschrift: | 8 |
| (Heft-)Nummer: | 5 |
| Kurzbeschreibung (Abstract): | We have identified a conserved G-quadruplex forming sequence in the 3' untranslated region (UTR) of the proto-oncogene PIM1. Circular dichroism and thermal denaturation studies revealed that the PIM1 mRNA guanine-rich sequence forms a highly stable intramolecular G-quadruplex structure. Reporter gene assay demonstrated that the PIM1 RNA G-quadruplex represses translation. It is the first experimental evidence of an RNA G-quadruplex structure located in the 3' UTR that may act as posttranscriptional regulator. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie > Synthetic Genetic Circuits (2020 umbenannt in "Synthetic RNA biology") 10 Fachbereich Biologie |
| Hinterlegungsdatum: | 22 Feb 2012 10:13 |
| Letzte Änderung: | 05 Mär 2013 09:58 |
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