Plugge, B. ; Gazzarrini, S. ; Nelson, M. ; Cerana, R. ; Etten, James L. van ; Derst, C. ; DiFrancesco, D. ; Moroni, Anna ; Thiel, Gerhard (2000)
A potassium channel protein encoded by chlorella virus PBCV-1.
In: Science (New York, N.Y.), 287 (5458)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
The large chlorella virus PBCV-1, which contains double-stranded DNA (dsDNA), encodes a 94-codon open reading frame (ORF) that contains a motif resembling the signature sequence of the pore domain of potassium channel proteins. Phylogenetic analyses of the encoded protein, Kcv, indicate a previously unidentified type of potassium channel. The messenger RNA encoded by the ORF leads to functional expression of a potassium-selective conductance in Xenopus laevis oocytes. The channel blockers amantadine and barium, but not cesium, inhibit this conductance, in addition to virus plaque formation. Thus, PBCV-1 encodes the first known viral protein that functions as a potassium-selective channel and is essential in the virus life cycle.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2000 |
| Autor(en): | Plugge, B. ; Gazzarrini, S. ; Nelson, M. ; Cerana, R. ; Etten, James L. van ; Derst, C. ; DiFrancesco, D. ; Moroni, Anna ; Thiel, Gerhard |
| Art des Eintrags: | Bibliographie |
| Titel: | A potassium channel protein encoded by chlorella virus PBCV-1. |
| Sprache: | Englisch |
| Publikationsjahr: | 2000 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Science (New York, N.Y.) |
| Jahrgang/Volume einer Zeitschrift: | 287 |
| (Heft-)Nummer: | 5458 |
| Kurzbeschreibung (Abstract): | The large chlorella virus PBCV-1, which contains double-stranded DNA (dsDNA), encodes a 94-codon open reading frame (ORF) that contains a motif resembling the signature sequence of the pore domain of potassium channel proteins. Phylogenetic analyses of the encoded protein, Kcv, indicate a previously unidentified type of potassium channel. The messenger RNA encoded by the ORF leads to functional expression of a potassium-selective conductance in Xenopus laevis oocytes. The channel blockers amantadine and barium, but not cesium, inhibit this conductance, in addition to virus plaque formation. Thus, PBCV-1 encodes the first known viral protein that functions as a potassium-selective channel and is essential in the virus life cycle. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie ?? fb10_botanik ?? 10 Fachbereich Biologie > Plant Membrane Biophyscis (am 20.12.23 umbenannt in Biologie der Algen und Protozoen) |
| Hinterlegungsdatum: | 22 Jun 2011 07:33 |
| Letzte Änderung: | 20 Aug 2021 09:43 |
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