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Complete genome sequence and analysis of Wolinella succinogenes.

Baar, C. and Eppinger, M. and Raddatz, G. and Simon, J. and Lanz, C. and Klimmek, O. and Nandakumar, R. and Gross, R. and Rosinus, A. and Keller, H. and Jagtap, P. and Linke, B. and Meyer, F. and Lederer, H. and Schuster, S. C. (2003):
Complete genome sequence and analysis of Wolinella succinogenes.
In: Proceedings of the National Academy of Sciences of the United States of America, pp. 11690-5, 100, (20), ISSN 0027-8424,
[Article]

Abstract

To understand the origin and emergence of pathogenic bacteria, knowledge of the genetic inventory from their nonpathogenic relatives is a prerequisite. Therefore, the 2.11-megabase genome sequence of Wolinella succinogenes, which is closely related to the pathogenic bacteria Helicobacter pylori and Campylobacter jejuni, was determined. Despite being considered nonpathogenic to its bovine host, W. succinogenes holds an extensive repertoire of genes homologous to known bacterial virulence factors. Many of these genes have been acquired by lateral gene transfer, because part of the virulence plasmid pVir and an N-linked glycosylation gene cluster were found to be syntenic between C. jejuni and genomic islands of W. succinogenes. In contrast to other host-adapted bacteria, W. succinogenes does harbor the highest density of bacterial sensor kinases found in any bacterial genome to date, together with an elaborate signaling circuitry of the GGDEF family of proteins. Because the analysis of the W. succinogenes genome also revealed genes related to soil- and plant-associated bacteria such as the nif genes, W. succinogenes may represent a member of the epsilon proteobacteria with a life cycle outside its host.

Item Type: Article
Erschienen: 2003
Creators: Baar, C. and Eppinger, M. and Raddatz, G. and Simon, J. and Lanz, C. and Klimmek, O. and Nandakumar, R. and Gross, R. and Rosinus, A. and Keller, H. and Jagtap, P. and Linke, B. and Meyer, F. and Lederer, H. and Schuster, S. C.
Title: Complete genome sequence and analysis of Wolinella succinogenes.
Language: English
Abstract:

To understand the origin and emergence of pathogenic bacteria, knowledge of the genetic inventory from their nonpathogenic relatives is a prerequisite. Therefore, the 2.11-megabase genome sequence of Wolinella succinogenes, which is closely related to the pathogenic bacteria Helicobacter pylori and Campylobacter jejuni, was determined. Despite being considered nonpathogenic to its bovine host, W. succinogenes holds an extensive repertoire of genes homologous to known bacterial virulence factors. Many of these genes have been acquired by lateral gene transfer, because part of the virulence plasmid pVir and an N-linked glycosylation gene cluster were found to be syntenic between C. jejuni and genomic islands of W. succinogenes. In contrast to other host-adapted bacteria, W. succinogenes does harbor the highest density of bacterial sensor kinases found in any bacterial genome to date, together with an elaborate signaling circuitry of the GGDEF family of proteins. Because the analysis of the W. succinogenes genome also revealed genes related to soil- and plant-associated bacteria such as the nif genes, W. succinogenes may represent a member of the epsilon proteobacteria with a life cycle outside its host.

Journal or Publication Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 100
Number: 20
Divisions: 10 Department of Biology > Microbial Energy Conversion and Biotechnology
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10 Department of Biology
Date Deposited: 07 Dec 2010 15:17
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