Gaudet, François ; Hodgson, J. Graeme ; Eden, Amir ; Jackson-Grusby, Laurie ; Dausman, Jessica ; Gray, Joe W. ; Leonhardt, Heinrich ; Jaenisch, Rudolf (2003)
Induction of tumors in mice by genomic hypomethylation.
In: Science (New York, N.Y.), 300 (5618)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of tumorigenesis has been unclear. To explore this phenomenon, we generated mice carrying a hypomorphic DNA methyltransferase 1 (Dnmt1) allele, which reduces Dnmt1 expression to 10% of wild-type levels and results in substantial genome-wide hypomethylation in all tissues. The mutant mice were runted at birth, and at 4 to 8 months of age they developed aggressive T cell lymphomas that displayed a high frequency of chromosome 15 trisomy. These results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2003 |
| Autor(en): | Gaudet, François ; Hodgson, J. Graeme ; Eden, Amir ; Jackson-Grusby, Laurie ; Dausman, Jessica ; Gray, Joe W. ; Leonhardt, Heinrich ; Jaenisch, Rudolf |
| Art des Eintrags: | Bibliographie |
| Titel: | Induction of tumors in mice by genomic hypomethylation. |
| Sprache: | Englisch |
| Publikationsjahr: | 2003 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Science (New York, N.Y.) |
| Jahrgang/Volume einer Zeitschrift: | 300 |
| (Heft-)Nummer: | 5618 |
| URL / URN: | http://www.cardoso-lab.org/publications/Gaudet_2003.pdf |
| Kurzbeschreibung (Abstract): | Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of tumorigenesis has been unclear. To explore this phenomenon, we generated mice carrying a hypomorphic DNA methyltransferase 1 (Dnmt1) allele, which reduces Dnmt1 expression to 10% of wild-type levels and results in substantial genome-wide hypomethylation in all tissues. The mutant mice were runted at birth, and at 4 to 8 months of age they developed aggressive T cell lymphomas that displayed a high frequency of chromosome 15 trisomy. These results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie ?? fb10_zoologie ?? 10 Fachbereich Biologie > Cell Biology and Epigenetics |
| Hinterlegungsdatum: | 06 Mär 2010 07:33 |
| Letzte Änderung: | 31 Okt 2018 13:53 |
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